ReviewCell death & disease2025
Intratumoral microbiota remodeling of the tumor microenvironment impact solid tumor immunotherapy.
Review in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Food-Derived Limosilactobacillus fermentum GR-3 Enhances Anti-PD-1 Immunotherapy Efficacy.Probiotics and antimicrobial proteins · 2026Article
- Microbial Influence on Immune Checkpoint Inhibitor Therapy in Non-Small Cell Carcinoma: The Gut-Lung-Immune Axis.Cancers · 2026Review
- Cell-free RNA Signatures Derived from the Tumor Microenvironment Predict Outcomes of CAR-T Therapy in Large B Cell Lymphoma.medRxiv : the preprint server for health sciences · 2026Article
- Interplay of Microbiome, Oxidative Stress and Inflammation in Health and Disease.Antioxidants (Basel, Switzerland) · 2026Review
- Programming the tumor microenvironment through microbiome-driven mechanisms.Frontiers in cellular and infection microbiology · 2026Review
- Spatial niches of the colorectal cancer microbiome: differences, interrelationships, and clinical implications of fecal, mucosal, and intratumoral microbiota.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor immunotherapy has significantly advanced in recent years. However, few patients with solid tumors respond to immunotherapy. The tumor microenvironment (TME) is a key factor in immunotherapy efficacy, and the intratumoral microbiota plays a significant role in remodeling the TME. Recent multiomic analyses revealed bacterial signatures in up to 76% of pancreatic ductal adenocarcinoma (PDAC) cases, and specific microbial consortia were linked to therapeutic resistance. Microbiota-targeted therapies, such as engineered bacterial strains, increase tumor clearance rates by approximately 30% in preclinical models. However, the complexity of microbial mechanisms and heterogeneity among individuals limit the clinical translation of intratumoral microbiota-based therapies. In this review, we provide an overview of intratumoral microorganisms, explore their influence on immune cells and signaling pathways in the TME, and discuss their potential value for improving the response of solid tumors to immunotherapy. Specifically, we examine the unique characteristics of intratumoral microbes in different types of solid tumors, emphasizing how tumor microsatellite status plays a key role in determining the effects of intratumoral microbes on the response of solid tumors to immunotherapy. Additionally, we discuss the clinical application of the intratumoral microbiota as a potential method for improving treatment efficacy and prognosis prediction in patients receiving immunotherapy for solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.