Evidence map›Paper›PMID 41326308›Full record

ArticleInfluenza and other respiratory viruses2025

Global Estimates of COVID-19 Morbidity and Mortality: A Cohort Study and Mathematical Model Analysis.

Houssein H Ayoub, Hiam Chemaitelly, Laith J Abu-Raddad

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. COVID-19, the disease that changed the world.Medicine and pharmacy reports · 2026
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Houssein H AyoubMathematics Program, Department of Mathematics and Statistics, College of Arts and Sciences, Qatar University, Doha, Qatar.ORCID 0000-0003-2512-6657
Hiam ChemaitellyInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.ORCID 0000-0002-8756-6968
Laith J Abu-RaddadInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.ORCID 0000-0003-0790-0506

Funding

Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research CoreJunior Faculty Transition to Independence Program at Weill Cornell Medicine-QatarL'Oréal-UNESCO For Women In Science Middle East Regional Young Talents ProgramMinistry of Public Health and Hamad Medical CorporationQatar Genome ProgrammeQatar Research Development and Innovation Council ARG02-0402-240119Qatar University QUCG-CAS-23/24-114
6 · The paper itself

Abstract

backgroundThe true extent of the severity and fatality caused by the COVID-19 pandemic remains uncertain. This study provides an approximate estimate of the global disease burden from the pandemic.

methodsA cohort study followed the Qatari population from the onset of the pandemic to March 18, 2024, to estimate the age-specific incidence rates of severe, critical, and fatal COVID-19, classified according to World Health Organization criteria. A mathematical model then utilized these rates to generate regional and global estimates of COVID-19 severity and fatality.

resultsThe incidence rate of any severe, critical, or fatal COVID-19 throughout the pandemic was 1.13 (95% CI: 1.07-1.19) per 1000 person-years, while that of fatal COVID-19 alone was 0.11 (95% CI: 0.09-0.13) per 1000 person-years. Globally, the number of severe, critical, or fatal COVID-19 cases was estimated at 61.9 million (95% UI: 55.0-69.9 million), while the number of fatal COVID-19 cases alone was estimated at 11.3 million (95% UI: 7.8-17.4 million). Both estimates showed large regional variations. Most severe, critical, and fatal COVID-19 cases occurred during the pre-Omicron phase of the pandemic.

conclusionsThe COVID-19 pandemic had a profound global impact on morbidity and mortality, emphasizing the critical need for preparedness for future pandemics.

Indexed as

COVID-19AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCohort StudiesFemaleGlobal HealthHumansIncidenceInfantMaleMiddle AgedModels, Theoreticalcohort studyepidemiologyfatalitymathematical modelSARS‐CoV‐2severity

Identifiers

PMID41326308
PMCPMC12981520

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.