ArticleThe journal of physical chemistry. A2025
Naphthalimide-Appended Squaraine Rotaxanes Exhibit Enhanced FRET Efficiency.
Article in The journal of physical chemistry. A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- 1,8-Naphthalimide: A Versatile Platform for the Design of Fluorescent Probes Targeting Hydrogen Sulfide in Biological Systems.Molecules (Basel, Switzerland) · 2026Review
- Manipulating excited-state dynamics through macrocycle positioning in a rotaxane for sensitive and discriminative methanol sensing.Chemical science · 2026Article
- Synthesis and preliminary assessment of fluorescent probes based on the competitive GPCR antagonists vismodegib and masupirdine.RSC advances · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fluorescent 1,8-naphthalimide dyes are often used as chemosensors and imaging agents, but there is a need for modified molecular designs that exploit Förster resonance energy transfer (FRET) to produce red-shifted emission wavelengths. This study compared the capacity of multicomponent 1,8-naphthalimide-squaraine and 1,8-naphthalimide-squaraine rotaxane conjugates to act as FRET pairs and produce a very large pseudo-Stokes shift. Evidence for FRET from a 1,8-naphthalimide donor to a squaraine acceptor included diagnostic changes in the fluorescence emission profile and a shorter 1,8-naphthalimide excited-state lifetime. FRET was more efficient when the conjugate's squaraine component was encapsulated as a rotaxane. Notably, the FRET efficiency for a 1,8-naphthalimide-squaraine rotaxane pentad increased in more polar solvents. To demonstrate potential as a practically useful chemosensor, a boronate-based analogue was synthesized and used to detect the presence of hydrogen peroxide in living cells by producing a ratiometric change in deep-red fluorescence with a pseudo-Stokes shift of 254 nm.
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Registered trials
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