Evidence map›Paper›PMID 41326002›Full record

ArticleNuklearmedizin. Nuclear medicine2026

Diagnosis of hepatic alveolar echinococcosis:18F-FDG-PET activity compared to the Echinococcus multilocularis Ulm Ultrasound Classification.

Wolfgang Kratzer, Sibylle Steinkellner, Dennis Skotnik, Lynn Peters, Beate Gruener, Nina Eberhardt

Abstract readComparative Study
In one paragraph

Article in Nuklearmedizin. Nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wolfgang Kratzer *Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Sibylle Steinkellner *Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Dennis SkotnikDepartment of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Lynn PetersDepartment of Internal Medicine III, Division of Infectious Diseases, Ulm University Hospital, Ulm, Germany.
Beate GruenerDepartment of Internal Medicine III, Division of Infectious Diseases, Ulm University Hospital, Ulm, Germany.
Nina EberhardtDepartment of Nuclear Medicine, Ulm University Hospital, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar echinococcosis (AE) is a rare, potentially fatal zoonosis with highly heterogeneous morphology. This study compares AE lesions in B-scan ultrasound, categorized according to the Echinococcus multilocularis Ulm Classification - Ultrasound (EMUC-US), with the maximum standardized uptake value (SUVmax) in 18F-Fluorodeoxyglucose Positron-Emission-Tomography (18F-FDG-PET/CT). 18F-FDG-PET/CT is the gold standard for evaluating disease activity, with SUVmax as the key parameter indirectly reflecting AE lesion activity.Retrospective analysis of data from the German National Echinococcosis Database. A total of 121 patients with 18F-FDG-PET/CT and B-scan ultrasound (US) between 2018-2019 were included. Based on EMUC-US, AE liver lesions were compared with the corresponding SUVmax in PET/CT. Additionally, SUV ratios (SUVTLR=tumor SUVmax/liver SUVmean) were calculated.The mean SUVmax, regardless of the EMUC-US subtype, was 6.0 ± 3.3 (range: 2.4-18.0). SUVmax comparison between subtypes shows significant differences (p<0.001). The highest SUVmax and SUVTLR were measured for the pseudocystic pattern with a mean of 9.2 ± 3.5 (range: 4.1-18.0). In contrast, the metastasis-like pattern yielded 3.7 ± 0.9 (range: 2.4-5.8) and the lowest SUVTLR. An SUVmax of 6.1 ± 3.3 (range: 2.6-16.8) was measured for the hailstorm pattern and 5.8 ± 2.2 (range: 3.6-10.4) for the hemangioma-like pattern.The results show significant differences between specific US patterns and the corresponding SUVmax. Lesions with very high or low SUV correlate with characteristic morphological patterns. Hence, in clinical practice B-scan can be a valuable bedside tool for assessing certain lesions. For evaluating inflammatory activity, 18F-FDG-PET/CT remains the method of choice.

Indexed as

Echinococcosis, HepaticEchinococcus multilocularisFluorodeoxyglucose F18Positron Emission Tomography Computed TomographyAdultAgedAged, 80 and overAnimalsEchinococcosisFemaleHumansMaleMiddle AgedRetrospective StudiesUltrasonographyYoung AdultFluorodeoxyglucose F18

Identifiers

PMID41326002
PMCPMC12880861

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.