Evidence map›Paper›PMID 41325835›Full record

ArticleJournal of advanced research2026

BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice.

Dan You, Yunzhong Zhang, Kunkun Wang, Luo Guo, Jin Guo, Chenhao Che, Wen Li, Liping Zhao, Huawei Li, Shan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dan YouENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Yunzhong ZhangENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Kunkun WangENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Luo GuoENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Jin GuoENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Chenhao CheENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Wen LiENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Liping ZhaoENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Huawei LiENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China. Electronic address: hwli@shmu.edu.cn.
Shan SunENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China. Electronic address: Shansun@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVestibular hair cells (HCs) are essential for maintaining balance and detecting head movements. In mammals, following vestibular damage HC regeneration derives from epithelial non-hair cells (ENHCs), which possess limited capacity for proliferation and reprogramming.

objectivesTo examine the role of BMP4 in reprogramming utricular HCs following ototoxic injury in postnatal mice.

methodsThe study utilized both wild-type mice and transgenic strains on a C57BL/6J background, including Notch1

resultsWe found that increased BMP4 expression enhances ENHC reprogramming, accompanied by elevated levels of key HC transcription factors, including Gfi1, Pou4f3, and Atoh1, via c-Fos activation. Moreover, exogenous BMP4 further sensitized ENHCs to Notch inhibition and Wnt pathway activation, thus amplifying the regenerative outcomes. Conversely, inhibition of c-Fos or BMP4 diminished these effects, demonstrating that BMP4 is essential for both Notch inhibition and Wnt activation. Notably, the use of a combination of small molecules targeting these pathways successfully restored vestibular function and promoted HC regeneration in adult mice.

conclusionOur findings suggest that BMP4 and its associated signaling pathways represent promising therapeutic targets for the restoration of hearing and balance.

Indexed as

Bone Morphogenetic Protein 4Cellular ReprogrammingRecovery of FunctionSaccule and UtricleStem CellsAnimalsCell DifferentiationCell ProliferationMaleMiceMice, Inbred C57BLMice, TransgenicRegenerationSignal TransductionBmp4 protein, mouseBone Morphogenetic Protein 4Adult miceBMP4 signalingc-FosProgenitor cellsVestibular function recovery

Identifiers

PMID41325835
PMCPMC13539158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.