Evidence map›Paper›PMID 41325780›Full record

ArticleBone & joint research2025

Implant design may influence knee flexor activation patterns during stair ascent and descent.

Alexis K Nelson-Tranum, Marcus C Ford, Nuanqiu Hou, Douglas W Powell, Christopher T Holland, Phyllis A Richey, William M Mihalko

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Article in Bone & joint research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alexis K Nelson-TranumThe University of Tennessee Health Science Center, College of Graduate Health Sciences, Memphis, Tennessee, USA.
Marcus C FordThe University of Tennessee Health Science Center - Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering, Memphis, Tennessee, USA.
Nuanqiu HouCampbell Clinic Foundation, Germantown, Tennessee, USA.
Douglas W PowellThe University of Tennessee Health Science Center, College of Graduate Health Sciences, Memphis, Tennessee, USA.
Christopher T HollandThe University of Tennessee Health Science Center - Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering, Memphis, Tennessee, USA.
Phyllis A RicheyThe University of Tennessee Health Science Center, College of Graduate Health Sciences, Memphis, Tennessee, USA.
William M MihalkoThe University of Tennessee Health Science Center - Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering, Memphis, Tennessee, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study examined the effects of surgical alignment techniques and implant design on sagittal plane moments and neuromuscular control during stair navigation in total knee arthroplasty (TKA) patients. We hypothesized that alignment techniques would affect joint biomechanics and neuromuscular control, while implant design would not influence lower limb biomechanics. Methods: A total of 52 TKA patients were analyzed one year postoperatively, categorized by alignment technique (mechanical alignment (MA) or kinematic alignment (KA)) and implant design (cruciate-retaining fixed bearing (CRFB), medial congruent (MC), and medial stabilized (MS)). Each participant performed five trials of overground walking, then stair ascent and descent at their preferred speed. Sagittal plane lower limb joint moments were calculated using a six-degree-of-freedom model in Visual 3D. Surface electromyography signals were analyzed over the entire gait cycle to assess muscle activation patterns. Results: The KA alignment group demonstrated greater knee extension moments and a knee-dominant strategy compared with the ankle-dominant strategy in the MA group. Implant design did not affect extension moments, but significantly impacted neuromuscular control. Implants with greater medial anteroposterior (AP) constraint showed lower biceps femoris (BF) activation, while designs with greater AP movement required higher BF activation. Conclusion: Surgical-alignment techniques, particularly KA, significantly impacted joint biomechanics, promoting a knee-dominant strategy during stair negotiation. Implant design influenced neuromuscular control, with less stable designs requiring higher hamstring activation for stabilization. Those results highlighted the importance of considering both alignment technique and implant design in post-TKA rehabilitation.

Identifiers

PMID41325780
PMCPMC12668820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.