Evidence map›Paper›PMID 41325600›Full record

ArticleJournal of participatory medicine2025

A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study.

Robin Ortiz, Joshua Joseph, Matthew P Johnson, Lainey Moen, Mathias Lalika, Clarence Jones, Irina Bancos, Lisa A Cooper, Sharonne N Hayes, Christi A Patten and 1 more

Abstract read
In one paragraph

Article in Journal of participatory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robin OrtizDepartments of Pediatrics and Population Health, New York University, Grossman School of Medicine, New York, NY, United States.ORCID https://orcid.org/0000-0002-0957-5850
Joshua JosephDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United States.ORCID https://orcid.org/0000-0001-9169-8261
Matthew P JohnsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0002-6341-7220
Lainey MoenDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0009-0003-4466-8336
Mathias LalikaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0003-0229-9942
Clarence JonesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0001-9030-2368
Irina BancosDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0001-9332-2524
Lisa A CooperDepartment of Medicine, Johns Hopkins University, Baltimore, MD, United States.ORCID https://orcid.org/0000-0001-6707-6390
Sharonne N HayesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0003-3129-362X
Christi A PattenDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0002-7194-8160
LaPrincess C BrewerDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.ORCID https://orcid.org/0000-0002-6468-9324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic stress in African American individuals is multilayered amid the context of experiences of racism and discrimination. Cortisol dynamic range (CDR) may be an indicator of chronic stress, but CDR is understudied in African American populations compared with White populations, and is hypothesized to differ by sex.

objectiveUsing a community-engaged approach within the Fostering African-American Improvement in Total Health! (FAITH!) Heart Health+ ancillary study, we assessed the feasibility of participant-centric CDR collection, and its association with measures for individual, interpersonal, and structural stress and exposure to racism in medically underserved African American women and men.

methodsParticipants residing in the Minneapolis-St Paul and Rochester, Minnesota areas provided survey data (everyday discrimination, perceived stress, mood, sleep quality, and high effort coping measures), and saliva samples (morning and afternoon) via at-home, self-collection kits for cortisol measurement. CDR was calculated as a difference in log cortisol levels (ie, log of the cortisol diurnal peak-to-nadir ratio). Geospatial Area Deprivation Index and the distance lived from George Floyd Square in Minneapolis were calculated. Linear regression examined the association between CDR and outcome variables.

resultsOf consented participants (n=53), 70% (37/53) provided cortisol samples. The final analytic sample included 32 participants with complete and physiological diurnal cortisol curves (mean age 57.5 years, 62.5% [20/32] women). Lower (less dynamic) CDR in women (n=20) was associated with greater perceived stress (β=-0.07, P=.01), greater anxiety (β=-0.06, P=.01), higher Superwoman Schema score (β=-0.02, P=.04), and greater distance from George Floyd Square (β=-0.02, P=.01). No associations were observed in men (P>.05).

conclusionsThe current results suggest that CDR from participant-led saliva collection is feasible and may serve as a biomarker of chronic and physiological stress in African American women, particularly those residing in underresourced areas.

Indexed as

African Americanscommunity engagementcortisolracismstress

Identifiers

PMID41325600
PMCPMC12706454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.