Evidence map›Paper›PMID 41325527›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.

Takafumi Sakai, Masahiro Kawakita, Arashi Seki, Katsuyoshi Takaoka, Misaki Kurata, Junpei Torikai, Sohshiroh Atsumi, Kanji Yawata, Kentaro Noi, Yosuke Fukutani and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Takafumi SakaiDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.ORCID 0009-0009-9533-6909
Masahiro Kawakita *Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Arashi Seki *Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Katsuyoshi Takaoka *Graduate School of Frontier Biosciences, Osaka University, Osaka, Suita 565-0871, Japan.ORCID 0009-0006-6758-9288
Misaki Kurata *Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Junpei TorikaiDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Sohshiroh AtsumiDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Kanji YawataDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Kentaro NoiDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.
Yosuke FukutaniDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.ORCID 0000-0002-3716-8590
Keiichi NoguchiDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.ORCID 0000-0003-0833-0808
Hirofumi KiyokawaLaboratory for Lung Development and Regeneration, RIKEN Center for Biosystems Dynamics Research, Hyogo, Kobe 650-0047, Japan.ORCID 0000-0001-8207-9688
Mitsuru MorimotoLaboratory for Lung Development and Regeneration, RIKEN Center for Biosystems Dynamics Research, Hyogo, Kobe 650-0047, Japan.ORCID 0000-0001-9132-4155
Eri TakeuchiDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Kodaira 187-8551, Japan.
Katsura MinegishiDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Kodaira 187-8551, Japan.ORCID 0000-0003-1567-2339
Yoshitsugu AokiDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Kodaira 187-8551, Japan.ORCID 0000-0002-9038-7506
Shoko FujimuraDepartment of Physics, Gakushuin University, Tokyo 171-8588, Japan.
Takayuki NishizakaDepartment of Physics, Gakushuin University, Tokyo 171-8588, Japan.
Takanari InoueDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-7957-7624
Kentaro NagaokaDepartment of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Fuchu 183-8538, Japan.ORCID 0000-0003-1038-1380
Hiroshi TsugawaDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.ORCID 0000-0002-2015-3958
Hisayoshi HayashiSchool of Food and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.ORCID 0000-0003-3615-4602
Hiroshi IshiguroDepartment of Human Nutrition, Nagoya University Graduate School of Medicine, Aichi, Nagoya 464-8601, Japan.ORCID 0000-0002-3603-0987
Takuma KozonoDepartment of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Fuchu 183-8509, Japan.ORCID 0000-0003-0253-9416
Ikuroh OhsawaResearch Teams for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.ORCID 0000-0002-7212-9298
Yasunori FujitaResearch Teams for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.ORCID 0009-0006-0334-7212
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710.
Hiroshi HamadaGraduate School of Frontier Biosciences, Osaka University, Osaka, Suita 565-0871, Japan.ORCID 0000-0002-7196-5948
Kyosuke ShinoharaDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Koganei 184-8588, Japan.ORCID 0000-0002-6350-1684

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP19K06560MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05307Takeda Medical Research Foundation No.1
6 · The paper itself

Abstract

Cilia are hair-like organelles that protrude from the cell surface. In mammals, tracheal multiciliated cells (MCCs) play an important role in elimination of hazardous microorganisms by driving a unidirectional mucus flow. Although uniform orientation of ciliary beating is critical for the unidirectional flow, it remains unknown how MCCs establish uniform orientations and maintain identities of hundreds of ciliary membranes. This study focuses on investigating the roles of Tubulin Polymerization Promoting Family Member 3 (Tppp3) in MCC function. We generated a Tppp3-deficient mouse (

Indexed as

Basal BodiesCiliaMicrotubulesSphingolipidsAnimalsHomeostasisMiceMice, KnockoutTracheaSphingolipidsbasal bodymicrotubulemotile ciliaolfactory sensory neurontrachea

Identifiers

PMID41325527
PMCPMC12704801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.