Evidence map›Paper›PMID 41325415›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Research Roadmap for Growth Disorders.

Evelien F Gevers, Anita C Hokken-Koelega, Maithe Tauber, Gerhard Binder, Elena G Bochukova, Sebastien G Bouret, Assumpta Caixàs, Justin H Davies, Andrew Dauber, Thomas Edouard and 11 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Evelien F GeversCentre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK, evelien.gevers@nhs.net.
Anita C Hokken-KoelegaDepartment of Paediatrics, Erasmus University Medical Centre Rotterdam, Sophia Children's Hospital, Rotterdam, The Netherlands.
Maithe TauberCentre de Référence Maladies Rares PRADORT (syndrome de Prader-Willi et autres Obésités Rares avec Troubles du comportement alimentaire), Hôpital des Enfants, CHU Toulouse, Université Toulouse III, Toulouse, France.
Gerhard BinderPediatric Endocrinology, University Children's Hospital, Tubingen, Germany.
Elena G BochukovaBlizard Institute, Barts and The London Medical School, Queen Mary University of London, London, UK.
Sebastien G BouretLaboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, University of Lille, Inserm, CHU Lille, Lille, France.
Assumpta CaixàsEndocrinology and Nutrition Department, Institut d'Investigació, Parc Taulí Hospital Universitari, Sabadell, Spain.
Justin H DaviesFaculty of Medicine, University of Southampton, Southampton, UK.
Andrew DauberDivision of Endocrinology, Children's National Hospital, Washington, District of Columbia, USA.
Thomas EdouardDepartment of Endocrinology, Bone Diseases and Genetics, Reference Centre for Rare Diseases of Growth and Development, FIRENDO Network, Children's Hospital, University Hospital of Toulouse, Toulouse, France.
Thomas EggermannCentre for Human Genetics and Genome Medicine, Medical Faculty, RWTH University Aachen, Aachen, Germany.
Eloise GiabicaniExplorations Fonctionelles Endocriennes, Centre de Recherche Saint Antoine, APHP, Sorbonne Universite, Paris, France.
Irène NetchineExplorations Fonctionelles Endocriennes, Centre de Recherche Saint Antoine, APHP, Sorbonne Universite, Paris, France.
Ola NilssonPediatric Endocrinology Unit and Center for Molecular Medicine, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Kristina SaravinovskaClinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, Serbia.
Manouk van der SteenDepartment of Pediatrics, Division of Endocrinology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
Marco TartagliaMolecular Genetics and Functional Genomics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Katrina Tatton-BrownSouth West Thames Regional Genomics Service, St George's University Hospitals NHS Foundation Trust, London, UK.
I Karen TempleFaculty of Medicine, University of Southampton, Southampton, UK.
Armelle YartRESTORE Research Centre, CNRS, INSERM, EFS, Université de Toulouse, Toulouse, France.
Martin ZenkerInstitute of Human Genetics, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At the national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Pediatric Endocrinology - aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in growth disorders was conducted to identify key research priorities, followed by broader stakeholder engagement, including society members and patient advocacy groups.

resultsResearch priorities encompass genetic diagnosis of growth disorders, growth plate-targeted therapies, molecular mechanisms of Silver-Russell syndrome and imprinting disorders, hypothalamic dysfunction in Prader-Willi syndrome, and characterization of Noonan syndrome and tall stature conditions. Emphasis is placed on creating disease registries to facilitate outcome studies and developing precision therapeutics based on growth regulation pathways.

conclusionsThis component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into growth disorder pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Indexed as

Biomedical ResearchDatabases, FactualEndocrinologyGrowth DisordersChildFemaleHumansMaleRegistriesGrowth hormoneImprinting disordersNoonan syndromePrader-Willi syndromeShort statureSilver-Russell syndromeTall stature

Identifiers

PMID41325415
PMCPMC12698128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.