Evidence map›Paper›PMID 41325413›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Research Roadmap for Thyroid Endocrinology.

Agnieszka Piekielko-Witkowska, Rossella Elisei, Juliane Léger, Bela Bendlova, Barbora Bulanová Pekova, Philippe Caron, Cosimo Durante, Martin Fassnacht, Ulla Feldt-Rasmussen, Helena Filipsson Nyström and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Agnieszka Piekielko-WitkowskaDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Centre of Translational Research, Warsaw, Poland.
Rossella EliseiUnit of Endocrinology, Department of Clinical and Experimental Medicine, Pisa University Hospital, Pisa, Italy, rossella.elisei@med.unipi.it.
Juliane LégerAP-HP, Nord Université Paris Cité, Service d'Endocrinologie et Diabétologie Pédiatrique, Centre de Référence Maladies Endocriniennes Rares de la Croissance et du Développement, Inserm U1141 NeuroDiderot, Hôpital Universitaire Robert-Debré, Paris, France.
Bela BendlovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Barbora Bulanová PekovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Philippe CaronDepartment of Endocrinology, Metabolic Diseases and Nutrition, Cardiovascular and Metabolic Unit, Larrey University Hospital, Toulouse, France.
Cosimo DuranteDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Martin FassnachtDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.
Ulla Feldt-RasmussenDepartment of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Helena Filipsson NyströmInstitute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Heleen JansenEndocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands.
Josef KöhrleCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Experimentelle Endokrinologie, Berlin, Germany.
Aleksander KusDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Marian LudgateSchool of Medicine, Cardiff University, Cardiff, UK.
Jonathan MertensLaboratory of Experimental Medicine and Paediatrics, Universiteit Antwerpen, Antwerp, Belgium.
Małgorzata Oczko-WojciechowskaDepartment of Clinical and Molecular Genetics, Maria Skłodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland.
Catherine PetersDepartment of Paediatric Endocrinology, Great Ormond Street Hospital for Children, London, UK.
Nadia SchoenmakersWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Athanasia StoupaPediatric Endocrinology, Gynecology and Diabetology Department, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.
Hanneke van SantenDepartment of Pediatric Endocrinology and Supportive Care, Wilhelmina Children's Hospital and Princess Máxima Center, Utrecht, The Netherlands.
Pierpaolo TrimboliClinic for Endocrinology and Diabetology, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Paul van TrotsenburgAmsterdam Gastroenterology Endocrinology and Metabolism Research Institute, Amsterdam, The Netherlands.
W Edward VisserDepartment of Internal Medicine, Erasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

resultsFor thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.

conclusionsThe thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Indexed as

Biomedical ResearchEndocrinologyThyroid DiseasesChildHumansAutoimmune thyroid diseaseCongenital hypothyroidismEndocrine-disrupting chemicalsGraves’ diseaseHashimoto’s thyroiditisMedullary thyroid cancerMicrobiomeSubclinical thyroid diseaseThyroidThyroid cancer

Identifiers

PMID41325413
PMCPMC12698131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.