Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Xinjie WangInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Xiao DuInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Zhishi ChenInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Wei YuInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Zhongjing WangInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Yanping ChenInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Daniel Y ChangWilliams College, Williamstown, Massachusetts, United States.
Garrett JensenInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.ORCID 0000-0001-8904-8737
Weijia LuoInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.
Jiang ChangInstitute of Biosciences and Technology, Center for Genomic and Precision Medicine, Texas A&M University Health Science Center, Houston, Texas, United States.ORCID 0000-0003-3707-7557
Funding
Metabolic Resuscitation in Heart Failure.R01HL176015 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Jiang Chang · 2024 to 2026
$2.2M
Epigenetic signaling, pathological cardiac hypertrophy and Western dietR01HL148133 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2020 to 2023
$2.2M
Epigenomic signaling and heart failure.R01HL150124 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2020 to 2023
$2.1M
Novel Insights into the Mechanistic Role of Small Rho GTPase in Chronic Cardiac Fibrotic RemodelingR01HL176744 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Weijia Luo · 2025 to 2026
$1.0M
Profiling communication networks of endogenous exosomesR21HL157708 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2021 to 2022
$417k
American Heart Association (AHA) 23TPA1142716HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148133HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL150124HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL176015HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL176744HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R21HL157708NHLBI NIH HHS R01 HL148133NHLBI NIH HHS R01 HL150124NHLBI NIH HHS R01 HL176015NHLBI NIH HHS R01 HL176744NHLBI NIH HHS R21 HL157708
6 · The paper itself
Abstract
Small extracellular vesicles (EVs) have become essential mediators of intercellular and interorgan communication in vivo, with significant therapeutic potential and prognostic value in cardiovascular diseases. Despite extensive research on exosomal cargoes and their biological effects, the in vivo dynamics and systemic distribution of cardiac-derived small EVs under pathological conditions remain poorly understood. This study used cardiac small EVs-tracking mice to profile the distribution and production of cardiomyocyte-derived small EVs following myocardial infarction (MI). We observed distinct temporal dynamics in cardiac small EVs uptake between males and females. In the heart, uptake increased markedly during the acute injury phase and declined during the healing phase in males, whereas it gradually declined in females, with both sexes showing preferential uptake by endothelial cells and leukocytes. The distribution of cardiac-derived small EVs in peripheral organs gradually decreased over time in male mice but followed different patterns in females. Females exhibited higher circulating levels of cardiac-derived small EVs and a more dynamic uptake into peripheral organs than males. Meanwhile, cardiac small EVs biogenesis tended to increase on
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dynamics and biodistribution of cardiomyocyte-derived small extracellular vesicles following myocardial infarction: sex differences. · full record | OpenQuestion