Evidence map›Paper›PMID 41324993›Full record

ArticleeLife2025

Nanophysiology approach reveals diversity in calcium microdomains across zebrafish retinal bipolar ribbon synapses

Nirujan Rameshkumar, Abhishek P Shrestha, Johane M Boff, Mrinalini Hoon, Victor Matveev, David Zenisek, Thirumalini Vaithianathan

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nirujan Rameshkumar *Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, United States.ORCID 0009-0006-7848-3390
Abhishek P Shrestha *Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, United States.ORCID 0000-0003-1576-8584
Johane M Boff *Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, United States.
Mrinalini HoonDepartment of Neuroscience, University of Wisconsin, Madison, United States.
Victor MatveevDepartment of Mathematical Sciences, New Jersey Institute of Technology, Newark, United States.ORCID 0000-0002-9867-5190
David ZenisekDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-6052-0348
Thirumalini VaithianathanDepartment of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, United States.ORCID 0000-0002-7686-5284

Funding

Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI Jonathan B Demb · 2016 to 2026
$7.1M
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.R01EY030863 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI VAITHIANATHAN, THIRUMALINI · 2021 to 2025
$2.3M
Dynamics of membrane tension and synaptic vesicle recyclingR01NS122388 · NINDS · YALE UNIVERSITY · PI KARATEKIN, ERDEM, MACHTA, BENJAMIN BROOKS · 2021 to 2025
$2.2M
Synaptic transmission at retinal ribbon synapsesR01EY032396 · NEI · YALE UNIVERSITY · PI THORESON, WALLACE B, ZENISEK, DAVID PAUL · 2021 to 2024
$1.9M
NEI NIH HHS 3R01EY030863-02S1NEI NIH HHS 3R01EY030863-03S1NEI NIH HHS P30 EY026878NEI NIH HHS P30EY026878NEI NIH HHS R01 EY030863NEI NIH HHS R01EY030863NEI NIH HHS R01 EY032396NEI NIH HHS R01NS122388NINDS NIH HHS R01 NS122388
6 · The paper itself

Abstract

Rapid and high local calcium (Ca

Indexed as

CalciumCalcium SignalingRetinal Bipolar CellsAnimalsMicroscopy, ConfocalZebrafishCalciumbipolar cellscalcium signalsnanodomainneuroscienceretinasynaptic vesicleszebrafish

Identifiers

PMID41324993
PMCPMC12668674

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.