Evidence map›Paper›PMID 41324990›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands.

Patricia Zamora Diaz, Tram Q Le, Laura Hurtado Osorio, Jenna F McQueen, Charissa A Bloom, Isabela Zimmermann Rollin, Vishnu Venkitasubramony, Laurelis E Santiago, Mengmeng Chang, Jerome W Breslin

Abstract read
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In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sigma-1 receptors, alcohol consumption, and arterial tone: a new intersection in cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Patricia Zamora DiazDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Tram Q LeDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Laura Hurtado OsorioDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Jenna F McQueenDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Charissa A BloomDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Isabela Zimmermann RollinDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0009-0005-0048-3967
Vishnu VenkitasubramonyDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0001-7751-2758
Laurelis E SantiagoDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Mengmeng ChangDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Jerome W BreslinDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-4867-3151

Funding

Microvascular Leakage in Hemorrhagic Shock and TraumaR35GM145379 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI JEROME W BRESLIN · 2022 to 2026
$2.0M
Human Resistance Artery Functional Changes with Alcohol UseR21AA029213 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI BRESLIN, JEROME W · 2022 to 2023
$374k
American Heart Association (AHA) 901052HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R21AA029213NIAAA NIH HHS R21 AA029213NIGMS NIH HHS R35 GM145379
6 · The paper itself

Abstract

Sigma receptor agonists are suspected to modulate blood pressure in humans. We investigated how modulation of sigma receptors impacts phenylephrine (PE)-induced contraction in human mesenteric arterial rings obtained from human organ donors. This study also explored the relationship between sigma receptor activation, PE-induced arterial contraction, and the history of the organ donor's alcohol use. The concentration responsiveness of PE-induced arterial contraction was tested using wire myography in the absence and presence of the sigma receptor agonist PRE-084, and the sigma receptor antagonists BD-1047 and SM-21. Sigma receptor-1 expression in the arteries was also investigated using an automated capillary electrophoresis system. The results show that PRE-084 elicited a downward shift in the PE concentration-response curve. Notably, this trend only occurred in arteries from donors with histories of non-/light drinking or moderate drinking (

Indexed as

Alcohol DrinkingEthanolMesenteric ArteriesReceptors, sigmaAdolescentAdultAgedAged, 80 and overChildDose-Response Relationship, DrugFemaleHumansIntestine, SmallLigandsMaleMiddle AgedEthanolLigandsPhenylephrineReceptors, sigmaSigma-1 ReceptorVasoconstrictor Agentsarterial constrictionarterial contractionhuman arteriessigma receptors

Identifiers

PMID41324990
PMCPMC12922482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.