Evidence map›Paper›PMID 41324829›Full record

ArticleInternational journal of bipolar disorders2025

Associations between negative symptoms and thermal pain perception in bipolar I disorder.

Lise Vrolix, Jon Haitz Legarreta, Hanne van der Heijden, Raquel van Gool, Aliza Ray, Emma Golden, Mariesa Cay, Yogesh Rathi, Joseph Gonzalez-Heydrich, Lauren J O'Donnell and 2 more

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Article in International journal of bipolar disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Lise VrolixNeuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Jon Haitz LegarretaDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Hanne van der HeijdenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Raquel van GoolDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Aliza RayBiostatistics and Research Design Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Emma GoldenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yogesh RathiDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Joseph Gonzalez-HeydrichDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Lauren J O'DonnellDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Ann K ShinnSchizophrenia and Bipolar Disorder Program, Psychotic Disorders Division, McLean Hospital, Belmont, MA, 02478, USA.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. jaymin.upadhyay@childrens.harvard.edu.

Funding

Joseph and Susan Gatto Award for Excellence in Imaging, Psychiatry and Drug Abuse A016626
6 · The paper itself

Abstract

backgroundThere is emerging evidence that negative symptoms are a source of functional impairment for individuals with bipolar I disorder (BD). Patients with BD may also demonstrate notable changes in the perception of pain. The objective of this preliminary study was to explore potential associations between negative symptom severity and pain perception (measured with quantitative sensory testing (QST)) in BD as well as identify neurobiological correlates of these two domains.

resultsIn patients with BD (N = 24, 30.3 ± 9.4 years of age), the Clinical Assessment Interview for Negative Symptoms (CAINS) Total and CAINS Motivation and Pleasure (MAP) subscale scores were associated with cold pain detection thresholds (CAINS Total: ρ = -0.49, p

conclusionThis preliminary study points to the relationship among negative symptom severity and the perception of pain in adults with BD. These findings suggest that thermal pain hypoalgesia in patients with BD may serve as a behavioral marker of negative symptoms, particularly in the MAP domain, potentially reflecting disruptions in sensory-affective integration. Further research with larger samples is warranted to clarify underlying neurobehavioral mechanisms.

Indexed as

Bipolar i disorderDiffusion tensor imagingNegative symptomsPainQuantitative sensory testingSuperior longitudinal fasciculus

Identifiers

PMID41324829
PMCPMC12698911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.