Evidence map›Paper›PMID 41324805›Full record

ArticleMolecular neurobiology2025

APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration.

Minjae Kang, Hwigyeong Kim, Yewon Jeon, Yoon Kyung Shin, Hwan Tae Park, Jung Eun Shin

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minjae KangPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea.
Hwigyeong KimPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea.
Yewon JeonPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea.
Yoon Kyung ShinPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea.
Hwan Tae ParkPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea.
Jung Eun ShinPeripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience, College of Medicine, Dong-A University, 32 Daesingongwon-Ro, Seo-Gu, Busan, 49201, Republic of Korea. jeshin20@dau.ac.kr.

Funding

National Research Facilities and Equipment Center 2021R1A6C101A425National Research Foundation of Korea 2020R1C1C1011074National Research Foundation of Korea RS-2023-00218515
6 · The paper itself

Abstract

Amyloid beta precursor-like protein 1 (APLP1), a member of the APP protein family, has been associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. However, its role in the peripheral nervous system remains unclear. Here, we demonstrate that APLP1 binds to sterile alpha and TIR motif-containing 1 (SARM1), an NAD

Indexed as

Amyloid beta-Protein PrecursorArmadillo Domain ProteinsAxonsCytoskeletal ProteinsNerve DegenerationAnimalsHumansMiceMice, Inbred C57BLProtein BindingSciatic NerveSensory Receptor CellsAmyloid beta-Protein PrecursorArmadillo Domain ProteinsCytoskeletal ProteinsSARM1 protein, humanSARM1 protein, mouseAPLP1Axon degenerationEmbryonic dorsal root gangliaGrowth coneSARM1

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.