ArticleLa Radiologia medica2026
Added value of diffusion-weighted imaging in detecting breast cancer missed by artificial intelligence-based mammography.
Article in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinically Robust Deep Learning for Contrast-Enhanced Mammography: Multicenter Evaluation Across Convolutional Neural Network Architectures.Bioengineering (Basel, Switzerland) · 2026Article
- Engineering the Image Representation for Deep Learning in Contrast-Enhanced Mammography: A Systematic Analysis of Preprocessing and Anatomical Masking.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveTo evaluate breast cancers missed by artificial intelligence-based computer-aided diagnosis (AI-CAD) in women newly diagnosed with breast cancer, identify factors associated with these missed cases, and assess the potential diagnostic value of standalone diffusion-weighted imaging (DWI) in detecting cancers overlooked by AI-CAD. MATERIALS AND
methodsThis retrospective study included 414 women (mean age, 55.3 years) with pathologically confirmed breast cancer who underwent preoperative mammography, MRI with DWI, and surgery. Cancers were classified as AI-detected if the lesion had an abnormality score greater than 10 and was correctly localized by AI-CAD; otherwise, they were categorized as AI-missed. Clinicopathologic and imaging features were compared between groups. Two radiologists independently reviewed DWI of AI-missed cancers and assigned malignancy confidence scores using a 6-point Likert-type scale (≥3 considered positive). Interobserver agreement and diagnostic performance were analyzed.
resultsAI-CAD missed 127 of 414 breast cancers (30.7%). Multivariate regression analysis identified dense breasts (adjusted OR = 1.619; p = 0.049) and tumor size ≤ 2 cm (adjusted OR = 4.698; p < 0.001) as independent predictors of AI-missed cancer. Standalone DWI detected 83.5% and 79.5% of AI-missed cancers for Radiologists 1 and 2, respectively, with substantial agreement (κ = 0.61). DWI was effective in detecting mammographically occult or >1 cm tumors, but sensitivity declined for subcentimeter lesions.
conclusionStandalone DWI detects the majority of breast cancers missed by AI-CAD, supporting its potential role as a triage adjunct in AI-based screening, particularly for dense breasts and mammographically occult lesions. However, the retrospective, cancer-only design limits generalizability, highlighting the need for prospective multicenter screening trials for validation.
Indexed as
Identifiers
41324774What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.