Evidence map›Paper›PMID 41324736›Full record

ArticleAnnals of biomedical engineering2026

Activated Platelet-Rich Plasma Fibrin Scaffolds Enhance Axonal Regeneration and Functional Recovery Following Spinal Cord Injury.

Leena R Chaudhari, Akshay A Kawale, Omkar Sonkawade, Mrunal Damle, Jitendra Patil, Sangeeta Desai, Meghnad G Joshi

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leena R ChaudhariDepartment of Stem Cell and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), E 869, D. Y. Patil Vidyanagar, Kasaba Bawada, Kolhapur, Maharashtra, 416006, India.
Akshay A KawaleDepartment of Stem Cell and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), E 869, D. Y. Patil Vidyanagar, Kasaba Bawada, Kolhapur, Maharashtra, 416006, India.
Omkar SonkawadeDepartment of Stem Cell and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), E 869, D. Y. Patil Vidyanagar, Kasaba Bawada, Kolhapur, Maharashtra, 416006, India.
Mrunal DamleStem Plus Biotech, SMK Commercial Complex, C/S No. 1317/2, Near Shivaji Maharaj Putla, Bus Stand Road, Gaon Bhag, Sangli, Maharashtra, 416416, India.
Jitendra PatilDepartment of Radiology, D Y Patil Medical College, Kolhapur, Maharashtra, 416003, India.
Sangeeta DesaiDepartment of Obstetrics and Gynecology, D Y Patil Medical College, Kolhapur, Maharashtra, 416003, India.
Meghnad G JoshiDepartment of Stem Cell and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), E 869, D. Y. Patil Vidyanagar, Kasaba Bawada, Kolhapur, Maharashtra, 416006, India. drmeghnadjoshi@gmail.com.

Funding

D.Y. Patil Education Society Institution Deemed to be University Kolhapur DYPES/DU/R&D/2023/261
6 · The paper itself

Abstract

purposeSpinal cord injury (SCI) is a devastating condition with limited therapeutic options owing to poor intrinsic regeneration and the formation of glial scars. Platelet-rich plasma (PRP)-based biomaterials have emerged as promising candidates for neural repair; however, their application in complete SCI models with rigorous multimodal validation has not yet been investigated. This study aimed to extend the current knowledge on SCI-PRP based study, by developing and comprehensively validating a clinically translatable PRP-derived fibrin scaffold for spinal cord regeneration.

methodsPRP-fibrin scaffolds were synthesized from donor-derived plasma and extensively characterized in terms of their physicochemical properties, degradation profiles, protein release dynamics, and cellular compatibility. Its regenerative potential was evaluated using an integrative pipeline that included in ovo chorioallantoic membrane (CAM) assays, a complete spinal cord transection rat model, and multimodal outcome measures, including magnetic resonance imaging (MRI), retrograde neuronal tract tracing, electrophysiological recordings, and gene expression analyses.

resultsThe scaffold exhibited favorable structural and biochemical characteristics, supported angiogenesis in the CAM assay, and promoted tissue integration in vivo. In an SCI model, the scaffold significantly enhanced neovascularization, reduced glial scarring, and facilitated axonal regeneration. Functional improvements were observed 30 days' post-implantation. In silico docking further demonstrated stable interactions between scaffold proteins and key neuroregenerative signaling molecules.

conclusionThis study provides multimodal validation of the derived fibrin scaffold, establishing it as a robust ECM-mimetic platform for spinal cord repair. These findings lay the groundwork for future clinical translation of SCI therapeutics.

Indexed as

AxonsNerve RegenerationPlatelet-Rich FibrinPlatelet-Rich PlasmaSpinal Cord InjuriesSpinal Cord RegenerationTissue ScaffoldsAnimalsFemaleHumansRatsRats, Sprague-DawleyRecovery of FunctionAxonal regenerationFunctional recoveryGlial scarPlatelet-rich plasma Fibrin scaffoldSpinal cord injury

Identifiers

PMID41324736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.