Evidence map›Paper›PMID 41324707›Full record

ArticleAnalytical and bioanalytical chemistry2026

Nanozyme-SERS dual-function sensor based on capillaries for the detection of Hcy in the serum of CRC patients.

Miaowen Xu, Dong Zhang, Tianran Li, Yanwen Zhuang, Zixun Wang, Xudong Zhang, Zhaohan Zhang, Lepeng Chen, Qiong Xu, Yayun Qian and 1 more

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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Miaowen Xu *School of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Dong Zhang *Department of Surgery, Guanyun People's Hospital, Lianyungang, 222200, People's Republic of China.
Tianran Li *School of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Yanwen ZhuangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Zixun WangThe First School of Clinical Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Xudong ZhangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Zhaohan ZhangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Lepeng ChenSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Qiong XuSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Yayun QianSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China. yyqian@yzu.edu.cn.
Limao LiDepartment of General Surgery, Jiangdu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225200, People's Republic of China. lilimao65056@163.com.

Funding

Project of Industry-University-Research Collaboration of Jiangsu Province BY20240547the Administration of Traditional Chinese Medicine Project of Jiangsu Province MS2021081Wellcome Trust 202341
6 · The paper itself

Abstract

This study developed a nanozyme-SERS dual-function sensor that exhibits both highly efficient peroxidase (POD)-like activity and superior surface-enhanced Raman spectroscopy (SERS) enhancement, designed for detecting homocysteine (Hcy) in serum from colorectal cancer (CRC) patients. Bimetallic Au@Pt nanoparticles (Au@Pt NPs) exhibited exceptional nanozyme catalysis and SERS performance, enabling the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to oxidized TMB (oxTMB) with a pronounced SERS signal generation. Au@Pt NPs were assembled into aminated capillaries via electrostatic adsorption and subsequently modified with Hcy aptamers to create the nanozyme-SERS dual-function sensor. When Hcy was present, the reducing thiol groups (-SH) consumed the hydroxyl radicals (·OH) produced by the decomposition of H

Indexed as

Biosensing TechniquesColorectal NeoplasmsHomocysteineMetal NanoparticlesSpectrum Analysis, RamanGoldHumansLimit of DetectionOxidation-ReductionPlatinumGoldHomocysteinePlatinum3,3′,5,5′-TetramethylbenzidineCapillaryColorectal cancerHydrogen peroxideNanoenzymesSurface-enhanced Raman spectroscopy

Identifiers

PMID41324707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.