Evidence map›Paper›PMID 41324672›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

National multicentered retrospective review of salvage therapy for pediatric medulloblastoma: a Canadian experience.

Michelle M Kameda-Smith, Melissa Lannon, Alysa Almojuela, Mark A MacLean, Amit Persad, Nicholas Sader, Arani Kulamurugan, Branavan Manoranjan, Craig Erker, Minoo Aminnejad and 11 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Michelle M Kameda-SmithDivision of Neurosurgery, McMaster University, Hamilton, ON, Canada. michelle.kameda@medportal.ca.ORCID 0000-0003-0904-9946
Melissa LannonDivision of Neurosurgery, McMaster University, Hamilton, ON, Canada.
Alysa AlmojuelaDivisision of Neurosurgery, University of Manitoba, Winnipeg, MB, Canada.
Mark A MacLeanDivision of Neurosurgery, Dalhousie University, Halifax, NS, Canada.
Amit PersadDivision of Neurosurgery, University of Saskatchewan, Saskatoon, SK, Canada.
Nicholas SaderDivision of Neurosurgery, University of Calgary, Calgary, AB, Canada.
Arani KulamuruganMcMaster Pediatric Brain Tumor Study Group (PBTSG), Hamilton, ON, Canada.
Branavan ManoranjanDivision of Neurosurgery, University of Calgary, Calgary, AB, Canada.
Craig ErkerDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Minoo AminnejadDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Bruce CooksDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Aleksander M VitaliDivision of Neurosurgery, University of Saskatchewan, Saskatoon, SK, Canada.
Walter HaderDivision of Neurosurgery, University of Calgary, Calgary, AB, Canada.
Simon WallingDivision of Neurosurgery, Dalhousie University, Halifax, NS, Canada.
P Daniel McNeelyDivision of Neurosurgery, Dalhousie University, Halifax, NS, Canada.
Blake YarascavitchMcMaster Pediatric Brain Tumor Study Group (PBTSG), Hamilton, ON, Canada.
Olufemi AjaniMcMaster Pediatric Brain Tumor Study Group (PBTSG), Hamilton, ON, Canada.
Forough FarrokhyarMcMaster Pediatric Brain Tumor Study Group (PBTSG), Hamilton, ON, Canada.
Adam FlemingMcMaster Pediatric Brain Tumor Study Group (PBTSG), Hamilton, ON, Canada.
Sheila K SinghDivision of Neurosurgery, McMaster University, Hamilton, ON, Canada.
Canadian Neurosurgery Research Collaborative (CNRC) in conjunction with the McMaster Pediatric Brain Tumour Study Group (PBTSG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn effective strategy for salvage therapy in refractory or relapsed childhood brain tumours is yet to be established.

methodsA national retrospective review of 135 children diagnosed with treatment refractory or recurrent MB from 2000 to 2021 at 5 academic Canadian pediatric neurosurgical centers was performed.

resultsThe mean age at diagnosis was 7.09 years (SD 4.37) with a male predominance (64.4%) and 17.8% under the age of 3 years. Most of the tumour histology was classic MB. Just over a third of children experienced disease progression during or after adjuvant therapy with an average disease-free interval of 17.55 months (SD 4.04). The majority of children experienced local disease progression (55.3%). Just over thirty percent of children succumbed to disease progression (n = 47, 34.8%). The mean age of first srelapse was 10.85 years (SD 7.10) and was identified on average 17.55 months (SD 9.76) from diagnosis. Most children with progressive disease (82.9%) were deceased at the time of writing. The mean time from first and second relapse to death was 27.19 months (SD 36.17) and 9.93 months (11.92) respectively. The cause of death was most commonly disease progression followed by a medical complication. Initial response to salvage therapy with recurrence and biopsy at index surgery were independently associated with mortality. The children were followed up for a mean interval of 83.17 months (SD 54.15).

conclusionRecurrent disease in childhood medulloblastoma after provision of upfront therapy confers a very poor prognosis despite salvage therapy and is an unmet need for further study and therapeutic development.

Indexed as

Cerebellar NeoplasmsMedulloblastomaNeoplasm Recurrence, LocalSalvage TherapyAdolescentCanadaChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesChildhood medulloblastomaRecurrenceRecurrentReirradiationSalvage therapyTreatment refractory

Identifiers

PMID41324672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.