Evidence map›Paper›PMID 41324670›Full record

ArticleSurgery today2026

Predictors and characteristics of late recurrence in non-small cell lung cancer patients 5 years or more after complete resection.

Dai Sonoda, Raito Maruyama, Yasuto Kondo, Masahito Naito, Masash Mikubo, Kazu Shiomi, Yukitoshi Satoh

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dai SonodaDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Raito MaruyamaDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Yasuto KondoDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Masahito NaitoDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Masash MikuboDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Kazu ShiomiDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Yukitoshi SatohDepartment of Thoracic Surgery , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. ysatoh@med.kitasato-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost cases of postoperative non-small-cell lung cancer (NSCLC) recurrence occur within 5 years of curative resection, with rare cases of late recurrence occurring after 5 years. However, the unique characteristics of late recurrence remain unclear. This study aimed to elucidate the characteristics and risk factors for late recurrence in patients with NSCLC.

methodsWe retrospectively analyzed 693 patients who underwent curative resection for NSCLC between 2004 and 2013. The primary endpoint was the identification of risk factors for late recurrence, that is, recurrence 5 years after resection.

resultsThe 5- and 10-year overall survival (OS) rates were 80.6% and 63.7%, respectively. Among the 435 patients who were recurrence-free for 5 years postoperatively, late recurrence occurred in 24(5.5%). A multivariate analysis identified age at resection (≥ 75 years) as a significant risk factor for late recurrence. Post-recurrence survival did not differ between patients with recurrence within five years and those with late recurrence.

conclusionsAge at resection (≥ 75 years) was a potential risk factor for late NSCLC recurrence. These patients require long-term follow-up and monitoring for up to five years after resection.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeoplasm Recurrence, LocalPneumonectomyAdultAgedAged, 80 and overAge FactorsFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSurvival RateLymphatic vesselsNon-small cell lung cancerRisk factors

Identifiers

PMID41324670

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