Evidence map›Paper›PMID 41324654›Full record

ReviewDer Nervenarzt2026

[Gender-specific aspects of psychopharmacotherapy].

Georgios Schoretsanitis, Chiara T Schmidt, Michael Paulzen

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Georgios SchoretsanitisPsychiatrische Universitätsklinik Zürich (PUK), Zürich, Schweiz.
Chiara T SchmidtKlinik für Psychiatrie, Psychotherapie und Psychosomatik, Medizinische Fakultät, RWTH Aachen, Aachen, Deutschland.
Michael PaulzenAlexianer Zentrum für seelische Gesundheit Aachen, Alexianergraben 33, 52062, Aachen, Deutschland. m.paulzen@alexianer.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the pharmacological treatment of mental disorders, gender-specific aspects are often ignored and guidelines also barely consider these aspects; however, male and female can react very differently to medications due to differences in pharmacokinetics and pharmacodynamics. This article provides an overview of gender-specific differences with a focus on the pharmacokinetics of psychotropic drugs. Furthermore, (life) phase-dependent differences are addressed considering the menstruation effect, the influence of oral contraceptives, pregnancy and menopause-related physiological alterations. Therapeutic drug monitoring (TDM) is a clinical instrument that can provide valuable contributions due to changing pharmacokinetics in order to optimize the efficacy and safety of pharmacotherapy in various phases of life.

Indexed as

Mental DisordersPsychotropic DrugsDrug MonitoringFemaleHumansMalePregnancySex CharacteristicsPsychotropic DrugsGender medicineMenstruationPregnancyPsychopharmacologyTherapeutic drug monitoring

Identifiers

PMID41324654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.