ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exploring Sex and Clinical Factors Associated with Long-Term Survival After Implantable Cardioverter-Defibrillator Implantation: A 10-Year Cohort Study.Journal of clinical medicine · 2026Article
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14 authors.
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Abstract
BACKGROUND AND
aimsImplantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy with defibrillation-function (CRT-D) are widely used in patients with life-threatening arrhythmias or heart failure. We aim to investigate the impact of sex-specific differences on defibrillation-capable cardiac devices' implantation and outcomes.
methodsThe German DEVICE registry is a prospective, multicentre database of ICD and CRT device implantation. A total of 5330 patients receiving a defibrillation-capable device were prospectively enrolled in 44 centres between March 2007 and February 2014 and followed for 17 (13, 23) months.
resultsA minority of patients in this registry was female 1017 (19.1%). The rate of CRT-D use among the defibrillator recipients was higher in women (32.4% vs. 28.0%; p = 0.006). The incidence of major periprocedural complications and in-hospital complications were higher in women (3.3% vs. 1.6%; p = 0.001 and 5.5% vs. 3.6%; p = 0.017, respectively). The 1-year all-cause mortality was 5.5% for women and 7.4% for men (p = 0.039), while the 1-year cardiovascular mortality was 4.1% and 6.2%, respectively (p = 0.012). Less women received device shocks during 1-year follow-up (10.7% vs. 13.8%; p = 0.023). Women receiving CRT-D had a lower non-device-related cardiovascular hospitalization rate than men. System revision until discharge, in-hospital death and non-fatal complications during follow-up were comparable for men and women. Similar rates of all-cause and cardiac rehospitalizations were found.
conclusionsIn this real-life patient cohort only a minority of patients was female. Female patients had a higher risk of major periprocedural complications and in-hospital complications but a lower all-cause and cardiovascular mortality. Less women experienced device-shocks during follow-up.
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