Evidence map›Paper›PMID 41324603›Full record

ArticleBriefings in bioinformatics2025

Systematic identification and characterization of virus lncRNAs suggests extensive structural mimicry of host lncRNAs.

Ping Fu, Zena Cai, Ruina You, Lei Deng, Zhaoyong Li, Zhichao Miao, Yousong Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Briefings in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ping FuBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.
Zena CaiBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.
Ruina YouBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.
Lei DengBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.
Zhaoyong LiBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.
Zhichao MiaoGMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory, Guangzhou Medical University, No. 190 Kaiyuan Road, Guangzhou Science Park, Luogang District, Guangzhou 510530, China.ORCID 0000-0002-5777-9815
Yousong PengBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, No. 27 Tianma Road, Yuelu District, Changsha, 410082, China.ORCID 0000-0002-5482-9506

Funding

Hunan Provincial Natural Science Foundation of China 2024JJ2015Major Project of Guangzhou National Laboratory GZNL2024A01002National Natural Science Foundation of China 32170651National Natural Science Foundation of China 32370700
6 · The paper itself

Abstract

Virus long noncoding RNAs (vlncRNAs) play crucial roles in viral infections, yet their identification and characterization remain limited. This study identified 5,053 novel vlncRNAs across 25 viral species using third-generation sequencing, with two from Influenza A virus and Vesicular stomatitis virus validated by RT-qPCR. Most vlncRNAs originated from dsDNA viruses. Only ~1% of vlncRNAs have annotated RNA families, suggesting many novel RNA structures. Interestingly, a total of 772 vlncRNAs from 15 human viruses structurally mimicked human lncRNAs (hlncRNAs), while only seven vlncRNAs shared sequence similarities with hlncRNAs. These vlncRNA and hlncRNAs bound to similar miRNAs, potentially acting as miRNA sponges to promote essential life processes. Splicing analysis showed vlncRNAs had a prevalence of alternative first exon. Finally, we developed vlncRNAbase (http://computationalbiology.cn/vlncRNAbase/#/) to store and organize the newly identified and known vlncRNAs. Overall, the study provides a valuable resource for further investigation into vlncRNAs and deepens our understanding of the diversity, structure, and function of the molecule.

Indexed as

Molecular MimicryRNA, Long NoncodingRNA, ViralHumansRNA, Long NoncodingRNA, Viralbioinformaticshost mimicrylong noncoding RNAsthird-generation sequencingvirus

Identifiers

PMID41324603
PMCPMC12667279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.