Evidence map›Paper›PMID 41324598›Full record

ArticleJournal of the American Chemical Society2025

A Trifunctional, Rare-Earth Theranostic Chelator Platform to Enable Diagnostic Nuclear Imaging, Surgical Resection, and Radiotherapy.

M Andrey Joaqui-Joaqui, Georgia G Sands, Dariusz Śmiłowicz, Mallory J Gork, Eduardo Aluicio-Sarduy, Todd E Barnhart, Jonathan W Engle, Eszter Boros

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Single Molecule EuJournal of the American Chemical Society · 2026
    Article
  3. Hydroxyquinoline-functionalised aza-crown macrocycles for lanthanide coordination.Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Andrey Joaqui-JoaquiDepartment of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53705, United States.ORCID 0000-0001-7446-6004
Georgia G SandsDepartment of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53705, United States.ORCID 0000-0002-1415-8568
Dariusz ŚmiłowiczDepartment of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53705, United States.
Mallory J GorkDepartment of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53705, United States.
Eduardo Aluicio-SarduyDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.ORCID 0000-0002-3399-7228
Eszter BorosDepartment of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53705, United States.ORCID 0000-0002-4186-6586

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NIH HHS S10 OD012245NIH HHS S10 OD020022NIH HHS S10 OD023526
6 · The paper itself

Abstract

Here, we establish a single-molecule, trifunctional platform compatible with diagnostic positron emission tomography (PET), optical imaging-assisted intrasurgical resection, and chelation of radiotherapeutic rare-earth nuclides. Building on previous pyridylalkynylaryl (PEPA) antenna scaffolds, mono- and bisantenna analogs incorporating either PEPA or methoxy-substituted MEPA chromophores were prepared to assess the role of pyridylalkynylaryl number and polyethylene glycol (PEG) substitution on photophysical and biological performance. Photophysical characterization with Eu(III) revealed that antenna truncation had minimal impact on quantum yields and Cerenkov radiation energy transfer (CRET) imaging while substantially improving water solubility. Biodistribution studies with Y-86-labeled analogs identified [

Indexed as

Chelating AgentsMetals, Rare EarthProstatic NeoplasmsTheranostic NanomedicineAnimalsHumansMiceOptical ImagingPositron-Emission TomographyTissue DistributionChelating AgentsMetals, Rare Earth

Identifiers

PMID41324598
PMCPMC12703665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.