Evidence map›Paper›PMID 41324407›Full record

ArticleAnnals of medicine2025

Association of serological biomarkers with muscle strength and function in sarcopenia: a cross-sectional study.

Wanling Huang, Ronghua Cao, Shuifen Ye, Huange Cai, Sihong Lin, Chunliu Huang, Jinrong Zhong, Xiaoli Li, Liming Tang, Dongqin Lai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wanling HuangGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Ronghua CaoNuclear Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Shuifen YeGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Huange CaiUltrasound Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou City, Fujian Province, China.
Sihong LinGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Chunliu HuangGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Jinrong ZhongGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Xiaoli LiGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Liming TangGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Dongqin LaiGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Fenjing LiGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Bin ChenGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.
Chunmei HuangGeneral Practice Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan City, Fujian Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study investigated the relationship between serological biomarkers and sarcopenia, with a focus on muscle strength and physical function. MATERIALS AND

methodsA cross-sectional exploratory study was conducted involving 77 patients admitted to the General Practice Department, Longyan First Affiliated Hospital of Fujian Medical University from April 2023 to April 2024. Patients were sorted into the sarcopenia group (

resultsPatients with sarcopenia had significantly lower fasting insulin, folate, and hemoglobin levels, as well as reduced calf circumference, handgrip strength, and 6-m walking speed (

conclusionFolate level is independently associated with sarcopenia. Serological biomarkers, including UA, 1,25-Hydroxy vitamin D3, albumin, hemoglobin, and GGT, may serve as indicators of muscle functionand potential targets for early intervention.

Indexed as

Muscle StrengthSarcopeniaAbsorptiometry, PhotonAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleFolic AcidHand StrengthHemoglobinsHumansInsulinMaleMiddle AgedMuscle, SkeletalBiomarkersFolic AcidHemoglobinsInsulinFolatemuscle functionpathogenesissarcopeniaserological biomarkers

Identifiers

PMID41324407
PMCPMC12671411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.