Evidence map›Paper›PMID 41324334›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer.

Nicole C Huning, Munir H Buhaya, Victor V Nguyen, Afeefah Khazi-Syed, Haider A Ali, Adil Khan, Angela Fan, Robert C Fisher, Zhikai Chi, Indu Raman and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Nicole C HuningDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Munir H BuhayaDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Victor V NguyenDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Afeefah Khazi-SyedDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Haider A AliDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Adil KhanDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Angela FanDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Robert C FisherDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhikai ChiDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Indu RamanDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Guangchun ChenDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Chengsong ZhuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Mengxi YuLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
Andrew R JamiesonLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
Sara RoccabiancaDepartment of Mechanical Engineering & Materials Science, Washington University at St. Louis, St. Louis, MO, 63130, USA.
Victor D VarnerDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Cheryl M LewisHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Emina H HuangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jacopo FerruzziDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.ORCID https://orcid.org/0000-0001-7195-589X

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
An organotypic model recapitulating colon cancer microenvironment and metastasisU01CA214300 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, SHEN, XILING · 2017 to 2021
$3.1M
The miR-20/c-Myc/E2F Regulatory Axis is Critical for the Tumor Promoting Activity of Inflammatory Fibroblasts in Colitis-Associated CancerR01CA237304 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, WESSELY, OLIVER · 2019 to 2023
$2.9M
High-performance slide scanner for multichannel fluorescence, brightfield and polarizationS10OD032267 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RAMIREZ, DENISE MARIE · 2022 to 2022
$208k
National Institutes of Health grant R01 CA234307National Institutes of Health grant U01CA214300NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA237304NCI NIH HHS U01 CA214300NIH HHS S10 OD032267University of Texas at Dallas Office of Research and Innovation through the CoBRA program 11748Wellcome Trust
6 · The paper itself

Abstract

While both incidence and mortality of sporadic average-onset colorectal cancer (AO CRC, above 50 years of age) are in constant decline, sporadic early-onset colorectal cancer (EO CRC, under 50 years of age) is rising rapidly. Yet, the causes behind this rise remain poorly understood. Epidemiological studies indicate that lifestyle and environmental exposures may result in chronic inflammation, which is known to trigger tissue fibrosis. This study tests the hypothesis that fibrotic remodeling and biomechanical stiffening of colorectal tissues represent measurable hallmarks and potential drivers of EO CRC. Using primary human tissues, this work shows that EO CRC is associated with changes in collagen microstructure, increased stiffness, and elevated viscosity of primary tumors. Spatial transcriptional profiling and immunostaining reveal pro-fibrotic signatures in stromal cells, alongside enhanced Yes-associated protein (YAP) mechanotransduction and proliferation in epithelial cells of EO CRC tissues. Mechanistically, increasing matrix stiffness in vitro promotes proliferation of epithelial cells in 2D and 3D colorectal cancer models. Together, these findings establish EO CRC as a disease marked by early and widespread biomechanical remodeling, suggesting that a fibrotic and stiffened tissue microenvironment may orchestrate EO CRC tumor initiation.

Indexed as

Colorectal NeoplasmsMechanotransduction, CellularBiomechanical PhenomenaFemaleHumansMaleMiddle AgedPhenotypeTumor Microenvironmentaverage‐onsetbiomechanicscolorectal cancerearly‐onsetfibrosisstiffnessYAP mechanotransduction

Identifiers

PMID41324334
PMCPMC12866780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.