Evidence map›Paper›PMID 41324261›Full record

ArticleeLife2025

Cross-species standardised cortico-subcortical tractography.

Stephania Assimopoulos, Shaun Warrington, Davide Folloni, Katherine Bryant, Ali-Reza Mohammadi-Nejad, Wei Tang, Saad Jbabdi, Sarah R Heilbronner, Rogier B Mars, Stamatios N Sotiropoulos

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Evidence for an Evolutionary Continuity in Social Dominance: Insights from Nonhuman Primate Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Stephania AssimopoulosSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0002-7321-6297
Shaun WarringtonSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0002-7198-8162
Davide FolloniNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Katherine BryantInstitute for Language, Cognition, and the Brain, CNRS, Université Aix-Marseille, Marseille, France.ORCID https://orcid.org/0000-0003-1045-4543
Ali-Reza Mohammadi-NejadSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0002-0710-6700
Wei TangLuddy School of Informatics, Computing and Engineering, Indiana University Bloomington, Bloomington, United States.
Saad JbabdiOxford Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-3234-5639
Sarah R HeilbronnerBaylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0003-0893-5364
Rogier B MarsOxford Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-6302-8631
Stamatios N SotiropoulosSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-4735-5776

Funding

BRAIN CONNECTS: Center for Mesoscale ConnectomicsUM1NS132207 · NINDS · UNIVERSITY OF MINNESOTA · PI TANER AKKIN, Damien A Fair · 2023 to 2026
$12.5M
Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivityR01MH118257 · NIMH · UNIVERSITY OF MINNESOTA · PI HEILBRONNER, SARAH RACHEL · 2019 to 2023
$1.9M
Neural Mechanisms and Neuromodulation of Affective StatesK99MH137315 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FOLLONI, DAVIDE · 2024 to 2025
$255k
European Research Council ERC 101000969Medical Research Council MR/Y010698/1NIH HHS NIH UM1NS132207NIMH NIH HHS K99 MH137315NIMH NIH HHS R01 MH118257NINDS NIH HHS UM1 NS132207Wellcome TrustWellcome Trust 10.35802/203139
6 · The paper itself

Abstract

Despite their importance for brain function, cortico-subcortical white matter tracts are under-represented in diffusion magnetic resonance imaging tractography studies. Their non-invasive mapping is more challenging and less explored compared to other major cortico-cortical bundles. We introduce a set of standardised tractography protocols for delineating tracts between the cortex and various deep subcortical structures, including the caudate, putamen, amygdala, thalamus, and hippocampus. To enable comparative studies, our protocols are designed for both human and macaque brains. We demonstrate how tractography reconstructions follow topographical principles obtained from tracers in the macaque and how these translate to humans. We show that the proposed protocols are robust against data quality and preserve aspects of individual variability stemming from family structure in humans. Lastly, we demonstrate the value of these species-matched protocols in mapping homologous grey matter regions in humans and macaques, both in cortex and subcortex.

Indexed as

Brain MappingCerebral CortexDiffusion Tensor ImagingWhite MatterAnimalsGray MatterHumansMacacaMaleamygdalofugalcortico-striatalcross-speciesdiffusion MRIexternal capsulehumanMuratoff bundleneurosciencerhesus macaquetractography

Identifiers

PMID41324261
PMCPMC12668672

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.