Evidence map›Paper›PMID 41324241›Full record

ArticleAmerican journal of hematology2026

New Insights Into Factors Shaping CMV-Specific T-Cell Polyfunctionality After Hematopoietic Cell Transplantation.

Alicja Sadowska-Klasa, Fang Yun Lim, Hu Xie, Danniel Zamora, Terry Stevens-Ayers, Wendy M Leisenring, Bradley C Edmison, Stephen C De Rosa, Marco Mielcarek, Michael Boeckh

Abstract read
In one paragraph

Article in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alicja Sadowska-KlasaFred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-7752-5839
Fang Yun LimFred Hutchinson Cancer Center, Seattle, Washington, USA.
Hu XieFred Hutchinson Cancer Center, Seattle, Washington, USA.
Danniel ZamoraFred Hutchinson Cancer Center, Seattle, Washington, USA.
Terry Stevens-AyersFred Hutchinson Cancer Center, Seattle, Washington, USA.
Wendy M LeisenringFred Hutchinson Cancer Center, Seattle, Washington, USA.
Bradley C EdmisonFred Hutchinson Cancer Center, Seattle, Washington, USA.
Stephen C De RosaFred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0003-3871-4618
Marco MielcarekFred Hutchinson Cancer Center, Seattle, Washington, USA.
Michael BoeckhFred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0003-1538-7984

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Cytomegalovirus-specific Immune Reconstitution after Hematopoietic Cell Transplantation in the Era of Modern Antiviral ProphylaxisK23AI163343 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Danniel Zamora · 2022 to 2026
$945k
Fred Hutchinson Cancer Research CenterGdański Uniwersytet MedycznyNCI NIH HHS P30 CA015704NIAID NIH HHS K23 AI163343NIH HHS CA15704NIH HHS K23AI163343
6 · The paper itself

Abstract

Polyfunctional cytomegalovirus (CMV)-specific T cells are critical for antiviral immunity in allogeneic hematopoietic cell transplantation (HCT) recipients. However, gaps remain in managing refractory CMV and optimizing virus-specific cellular therapy (VST). We conducted a comparative analysis of how timing and dosing of immunosuppressive agents, including post-transplant cyclophosphamide (PT-Cy), corticosteroids, mycophenolate mofetil (MMF), and calcineurin inhibitors (CNIs), shape CMV-specific T-cell polyfunctionality. CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsHematopoietic Stem Cell TransplantationImmunosuppressive AgentsAdrenal Cortex HormonesAdultAgedCyclophosphamideCyclosporineFemaleHumansMaleMiddle AgedMycophenolic AcidAdrenal Cortex HormonesCyclophosphamideCyclosporineImmunosuppressive AgentsMycophenolic AcidCMV‐specific T cellsdrug effectsHCTimmunosuppressive treatment

Identifiers

PMID41324241
PMCPMC12766359

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.