ArticleJournal of musculoskeletal & neuronal interactions2025
Sarcopenia and Muscle Dysfunction in Osteogenesis Imperfecta: Insights from A Pilot Study.
Article in Journal of musculoskeletal & neuronal interactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveThis study aimed to assess the prevalence of sarcopenia in adult patients with osteogenesis imperfecta (OI) and to identify its associated factors.
methodsSeventeen adult OI patients and 17 adult healthy controls matched for age, sex, and BMI were included. Assessments included handgrip strength (HGS), ultrasonographic muscle measurements, the International Physical Activity Questionnaire (IPAQ), Upper and Lower Extremity Functional Indices (UEFI & LEFI), the SARC-F questionnaire, and laboratory markers.
resultsLeft-handgrip strength was significantly lower in OI patients than in controls (21.8±4.9 kg vs. 25.3±4.2 kg, p = 0.034). Four OI patients had a SARC-F score ≥4, whereas none in the control group did. Handgrip strength was negatively correlated with thigh fat thickness (r = - 0.604, p = 0.010) and free T4 levels (p < 0.05) but positively correlated with gastrocnemius thickness, serum calcium, albumin, and triglycerides (p < 0.05).
conclusionRoutine muscle strength assessments should be considered an integral component of OI management to optimize patient outcomes. This work is a pilot, hypothesis‑generating study; its preliminary findings require confirmation in larger cohorts with formal power calculations.
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41324214PMC12684263What OpenQuestion holds
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