ArticleJournal of musculoskeletal & neuronal interactions2025
Calvarial Bone Defects Heal Better in Short-Term Ovariectomized Rats Compared to Healthy Rats.
Article in Journal of musculoskeletal & neuronal interactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
objectivesPostmenopausal women develop estrogen deficiency which produces a pro-resorptive bone environment, leading to osteoporosis and increased fracture risk. Craniectomies are a common clinical procedure, especially in older populations, where calvarial bone is removed to relieve intracranial pressure (i.e., in the case of traumatic brain injury or stroke). Cranial reconstruction surgeries often result in failure due to infection or resorption of autograft material. Despite the need for calvarial bone graft alternatives for older patients, there is limited literature available on the effects of estrogen deficiency on skull bone metabolism and healing.
methodsThe purpose of this work was to assess the effects of short-term ovariectomy (OVX) on calvarial bone properties and on the healing of 3.5 mm unilateral calvarial defects.
resultsSurprisingly, the intact calvarial bone of OVX rats had higher bone volume, thickness, and number of remodeling cavities than intact calvaria of sham rats. Normalized measures of bone volume showed consistently more calvarial defect healing in OVX compared to sham rats at 4-, 8-, and 12-weeks post-surgery.
conclusionThese findings have implications for future investigations on therapies for treating calvarial bone defects in ovariectomy-induced osteoporotic rats.
Indexed as
Identifiers
41324210PMC12684264What OpenQuestion holds
Registered trials
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