ArticleHealth science reports2025
Evaluation of the Effect of Topical Vitamin A Eye Ointment on Pain Reduction and Accelerated Healing of Corneal Defect After Photorefractive Keratectomy: A Prospective Randomized Controlled Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Photorefractive keratectomy (PRK) is commonly used for refractive errors but is associated with postoperative pain and delayed epithelial healing. Vitamin A has been shown to support epithelial regeneration and corneal wound healing. This study aimed to evaluate the effect of topical vitamin A (retinol palmitate) on postoperative pain and corneal epithelial healing after PRK. Methods: A double-blind, randomized controlled trial was conducted on 56 eyes of 28 myopic patients undergoing PRK at Imam Khomeini Hospital, Ahvaz, Iran. Participants were assigned to a vitamin A ointment group (250 IU/g in a petrolatum-based ointment) or a control group. The primary outcome was corneal epithelial healing, and the secondary outcome was postoperative pain, measured using the visual analog scale (VAS). Results: Corneal healing was significantly faster in the vitamin A group, with smaller epithelial defects at 24 h (19.32 ± 6.21 mm² vs. 26 ± 8.28 mm², Conclusion: Topical vitamin A accelerated corneal epithelial healing after PRK, especially in the first 3 days post-surgery. However, it did not significantly reduce postoperative pain. These results suggest vitamin A aids in wound healing, but its role in pain management after PRK remains unclear. Larger studies with longer follow-up are needed to explore its effects further.
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