ArticleHealth science reports2025
Comparison of Sofia 2 Respiratory Syncytial Virus Fluorescent Immunoassay to Real-Time Polymerase Chain Reaction Assay in Children Under Two Years Old Hospitalized With Acute Respiratory Illness in Amman, Jordan: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
16 authors.
Funding
Abstract
Background and Aims: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection (ARI) in children, particularly in low- and middle-income countries. Rapid diagnosis is important for management and infection control. We aimed to evaluate diagnostic accuracy of Sofia 2 RSV fluorescent immunoassay (FIA) compared to reverse-transcription quantitative PCR (RT-qPCR) in children under 2 years hospitalized with ARI in Amman, Jordan. Methods: We conducted a prospective viral surveillance study from January 26, 2020 to March 17, 2020, at Al-Bashir Hospital. Sofia 2 RSV FIA was performed on nasal swabs and compared to RT-qPCR. We calculated sensitivity, specificity, and Cohen's Results: Of 458 children enrolled, 356 (77.7%) had RSV detected by RT-qPCR. Sofia 2 RSV FIA demonstrated 76.1% sensitivity (95% CI: 71.3, 80.5%) and 94.1% specificity (95% CI: 87.6, 97.8%) relative to RT-qPCR. Lower RT-qPCR cycle threshold value (inversely related to viral load) was significantly associated with Sofia 2 RSV FIA positivity (aOR = 0.75; 95% CI: 0.70, 0.81; Conclusion: Sofia 2 RSV FIA demonstrates potential as a rapid diagnostic test in resource-limited settings. Further research on its clinical outcomes and cost-effectiveness could enhance RSV management in children.
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