Evidence map›Paper›PMID 41324081›Full record

ArticleFrontiers in cellular neuroscience2025

Delayed onset of striatal projection neuron hyperexcitability in

Lars Nelson, Michael Janeček, Michael Matarazzo, Yi-Chun Shih, Rui T Peixoto

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lars NelsonDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Michael JanečekDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Michael MatarazzoDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Yi-Chun ShihDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Rui T PeixotoDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.

Funding

Training for Transformative Discovery in PsychiatryT32MH016804 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2025
$6.2M
Mechanisms and pathogenic role of early corticostriatal dysfunction in Shank3B-/- miceR01MH124695 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2021 to 2025
$2.0M
Role of local interneurons in early cortical dysfunction in Shank3 KO miceR21MH132015 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2023 to 2023
$437k
NIMH NIH HHS R01 MH124695NIMH NIH HHS R21 MH132015NIMH NIH HHS T32 MH016804
6 · The paper itself

Abstract

Introduction: Fragile X Syndrome (FXS), the most common genetic cause of intellectual disability and autism spectrum disorder (ASD), results from silencing of the Methods: We examined the postnatal maturation of SPNs in the dorsomedial striatum (DMS) of Results: During postnatal development, Discussion: These findings reveal that DMS SPN hyperexcitability in

Indexed as

autism spectrum disorderFmr1Fragile Xneurodevelopmentstriatal projection neuronstriatum

Identifiers

PMID41324081
PMCPMC12657441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.