ArticleFrontiers in nutrition2025
Malnutrition and sarcopenia: a combined risk factor for vascular calcification and cardiovascular events in hemodialysis patients.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures.EXCLI journal · 2026Review
- Latent Classes of Inflammation-Nutrition-Metabolism Status in Maintenance Hemodialysis: Associations with Arteriovenous Fistula Function and Cardiovascular Prognosis.Journal of multidisciplinary healthcare · 2026Article
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7 authors.
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Abstract
Background: Hemodialysis (HD) patients are at high risk of vascular calcification (VC) and cardiovascular disease (CVD). The coexistence of sarcopenia and malnutrition, known as malnutrition-sarcopenia syndrome (MSS), may further exacerbate these risks. This study aimed to investigate the prevalence of MSS in HD patients and its association with abdominal aortic calcification (AAC) and major adverse cardiovascular events (MACE). Methods: This prospective cohort study enrolled 462 maintenance HD patients, who were subsequently stratified into four groups: no sarcopenia-no malnutrition, sarcopenia alone, malnutrition alone, and MSS. Sarcopenia was diagnosed based on the 2019 Asian Working Group for Sarcopenia (AWGS) criteria, and malnutrition was assessed using the Geriatric Nutritional Risk Index (GNRI). AAC was evaluated using lateral abdominal radiographs and scored according to Kauppila's semiquantitative scoring system. The primary outcome was MACE during a 3-year follow-up period. Multivariable logistic regression and mediation analyses were employed to determine associations and potential mechanisms. Results: The prevalence of sarcopenia and malnutrition was 46.3 and 32.0%, respectively, with 18.2% of patients having MSS. MSS was independently associated with increased AAC (OR: 2.157, 95% CI: 1.064-4.373, Conclusion: MSS is prevalent in HD patients and is associated with more severe VC and higher cardiovascular risk. Comprehensive nutritional assessment and targeted interventions are needed to address sarcopenia and malnutrition in HD patients to improve their cardiovascular outcomes.
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