Evidence map›Paper›PMID 41323957›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2025

Immune Monitoring Goes Viral - Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation.

Konstantin Doberer, Sebastian Kapps, Frederik Haupenthal, Gregor Bond

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Transplant International: Looking Back at 2025, Looking Forward to 2026.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  7. Nurturing a Sustainable Transplantation Journey: the best of ESOT Congress 2025.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Konstantin DobererDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Sebastian KappsDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Frederik HaupenthalDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Gregor BondDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using biomarkers to tailor immunosuppressive therapy after kidney transplantation was proposed to improve clinical care. Timely and individual adaptions of immunosuppression could reduce therapy-related side effects, such as infections, cardiovascular morbidity and malignancy, and further lower the risk of allograft rejection. Despite promising preliminary studies, evidence for implementing such a biomarker in clinical care is insufficient. Prominent candidates for immunologic monitoring after kidney transplantation include donor human leukocyte antigen-specific antibodies, donor-derived cell-free DNA, urinary chemokines and peripheral transcriptomics. In addition, the quantification of Torque Teno virus, a highly prevalent and non-pathogenic virus that was shown to associate with outcomes linked to immunocompetence, has been proposed for immunologic monitoring. This review summarises the prospects and limitations of Torque Teno virus for immunologic risk stratification after kidney transplantation in the context of current state-of-the-art. It will focus on cut-off values of plasma Torque Teno virus load that might be useful to guide immunosuppression in the clinical care of kidney transplant recipients, and highlights recently proposed indications of Torque Teno virus-guided immunosuppression.

Indexed as

DNA Virus InfectionsKidney TransplantationTorque teno virusBiomarkersGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsMonitoring, ImmunologicRisk AssessmentViral LoadBiomarkersImmunosuppressive Agentsbiomarkerimmune monitoringkidney transplantationrisk stratificationtorque teno virus

Identifiers

PMID41323957
PMCPMC12660151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.