Evidence map›Paper›PMID 41323858›Full record

ArticleNational science review2025

Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics.

Hai-Jun Wen, Hua-Juan Ma, Gong-Xun Zhong, Ao Ding, Xi Wang, Xiao-Ju Lai, Chang-Hao Shi, Miles Tracy, Si-Jin Wu, Jia-Sheng Li and 25 more

Abstract read
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Hai-Jun WenState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Hua-Juan MaCancer Center, Clifford Hospital, Jinan University, Guangzhou 511495, China.
Gong-Xun ZhongState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Researched Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.ORCID https://orcid.org/0000-0002-0748-9641
Ao DingState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Xi WangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Xiao-Ju LaiState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Chang-Hao ShiState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Miles TracyState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Si-Jin WuAcademy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Jia-Sheng LiState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Ge ZhangCancer Center, Clifford Hospital, Jinan University, Guangzhou 511495, China.
Yong-Bo YaoCancer Center, Clifford Hospital, Jinan University, Guangzhou 511495, China.
Wei ChenCancer Center, Clifford Hospital, Jinan University, Guangzhou 511495, China.
Xue-Yu LiuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Zhi-Chao XuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Xue CaoDepartment of Laboratory Animal Science, Kunming Medical University, Kunming 650500, China.
Wen-Bin HeState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China.
Jing FengState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China.
Guo-Dong WangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China.ORCID https://orcid.org/0000-0002-9407-4363
Feng-Liang LiuKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences / Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Wei-Shun ZengState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Guang-An LuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Jia-Yu GuoState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Yong-Tang ZhengKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences / Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.ORCID https://orcid.org/0000-0002-0345-1945
Hui ZengBeijing Ditan Hospital, Capital Medical University, Beijing 100102, China.ORCID https://orcid.org/0000-0002-7456-6061
Xiong-Lei HeState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID https://orcid.org/0000-0003-1050-802X
Fu-Jie ZhangBeijing Ditan Hospital, Capital Medical University, Beijing 100102, China.ORCID https://orcid.org/0000-0001-6386-9879
Zhi-Hong HuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Xue-Mei LyuState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China.
Hualan ChenState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Researched Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Xin-Xing LeiDepartment of Laboratory Medicine, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University)  Shenzhen 518020, China.
Jian LiHangzhou MinSheng Pharm. Group, Hangzhou 310005, China.
Man-Li WangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Qi-Chun CaiCancer Center, Clifford Hospital, Jinan University, Guangzhou 511495, China.
Chung-I WuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme in anticipation of a fourth one. We here present a scheme that could clear SARS-CoV-2 in 2-4 days post-infection from the upper respiratory tract (URT), where the virions are initially concentrated. The scheme, applicable on a large scale by nasal spray, is based on homoharringtonine (HHT), which has been approved for treating other diseases. HHT blocked protein elongation and repressed

Indexed as

coronavirushomoharringtonineSARS-CoV-2

Identifiers

PMID41323858
PMCPMC12661574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.