ArticleFood science & nutrition2025
Food-Herb Dual-Function in Astragali Radix-Poria-Rheum: Network Pharmacology and Database Mining for Diabetic Kidney Disease Mechanisms Exploration.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Food-Herb Dual-Function in Astragali Radix-Poria-Rheum: Network Pharmacology and Database Mining for Diabetic Kidney Disease Mechanisms Exploration.Food science & nutrition · 2025Article
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9 authors.
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Abstract
The growing demand for functional foods derived from medicinal-edible homologous resources offers a promising strategy to address the chronic metabolic dysregulation underlying diabetic kidney disease (DKD), particularly in patients requiring long-term pharmacological interventions. DKD, a metabolic disorder-driven complication of diabetes, is characterized by chronic hyperglycemia, insulin resistance (IR), and systemic metabolic dysregulation, necessitating novel dietary approaches to complement conventional therapies. To systematically explore the therapeutic potential of medicinal-edible homologous herbs in DKD management, this study retrieved clinical literature from the China National Knowledge Infrastructure (CNKI) database, focusing on traditional Chinese medicines (CHMs) with dual dietary and therapeutic functions. By integrating data mining techniques (frequency analysis, attribute-flavor analysis, herb-pair co-occurrence networks, and cluster analysis) with expert clinical consensus, we prioritized the identification of core medicinal-edible homologous combinations that align with DKD's metabolic pathology. This multi-dimensional approach revealed Huangqi (
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