ArticleBiochemistry and biophysics reports2025
Single-cell RNA sequencing reveals immune cell alterations in patients with allergic rhinitis treated with Peiyuan Tong-qiao decoction.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamic CD4+ T Cell Genetics Identifies Candidate Therapeutic Targets for Allergic Rhinitis: Mendelian Randomization with Exploratory Single-Cell Contextualization.Biomedicines · 2026Article
- Identification of EGR2 and TGFB1 as Potential Immunoregulatory Biomarkers for Allergic Rhinitis: An Exploratory Bioinformatics and Pilot Validation Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Understanding the immune microenvironment of ovarian cancer.Frontiers in oncology · 2026Review
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Authors and funding
7 authors.
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Abstract
Allergic rhinitis (AR) is a chronic inflammatory disease with complex causes. Traditional Chinese medicine (TCM) shows promise for treating AR. This study aimed to explore the mechanisms behind TCM's effectiveness. In this study, we collected peripheral blood mononuclear cells (PBMCs) from AR patients before and after TCM treatment. Single-cell RNA sequencing (scRNA-seq) was performed to identify cell types and differentially expressed genes (DEGs) and analyzed immune cell pathways to understand how TCM treats AR. Cell-cell communication and regulatory networks were also investigated. Accordingly, 11 major cell types were annotated. The strength of the outgoing interaction between CD14
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