ArticleBiochemistry and biophysics reports2025
Immunofluorescence staining profiles of glomerular diseases: a single-center retrospective study.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- GloPath: An Entity-Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunofluorescence (IF) staining is essential for diagnosing glomerular diseases, yet comprehensive characterization of immune deposition patterns remains limited. We retrospectively analyzed 10,489 consecutive native kidney biopsies (2011-2022) from a tertiary center. IF staining for IgA, IgG, IgM, C1q, C3, C4d, and fibronectin was semi-quantitatively graded (0-4+) and deposits classified as mesangial area only (MAO), glomerular capillary loop only (GCLO), or combined mesangial-capillary loop (MA-GCL). IgA nephropathy (IgAN) was the most frequent diagnosis (38.4 %), followed by membranous nephropathy (16.8 %) and focal segmental glomerulosclerosis (13.7 %). IgA deposition was universal in IgAN and IgA vasculitis nephritis (IgAVN), predominantly mesangial (84 % and 78 %, respectively), with MA-GCL co-deposition in 16-21 % of cases. Co-deposition with IgM (58 %), C3 (67 %), and C4d (15 %) was frequent in IgAN. Correlation analysis revealed significant associations between mesangial IgA intensity and mesangial IgM (ρ = 0.26), C3 (ρ = 0.61), C4d (ρ = 0.31), and glomerular C4d (ρ = 0.35) (all P < 0.05), while IgAVN showed additional correlation with fibronectin (ρ = 0.35). C4d positivity was also observed in hypertensive nephropathy (54.7 %). These findings define disease-specific IF profiles and highlight complement activation and fibronectin deposition as potential contributors to IgA-mediated glomerular injury. Integration of quantitative IF data with clinical outcomes may improve risk stratification and inform complement-targeted therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.