ArticleGlobal advances in integrative medicine and health
Hepatoprotective Effect of
Article in Global advances in integrative medicine and health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Paracetamol is one of the popular causes of liver injury primarily mediated by oxidative stress and increased inflammation within the liver. Objective: This study was aimed at evaluating the hepatoprotective effect of a methanolic extract of Methods: The study was conducted on thirty male Swiss albino mice, randomly grouped into six groups of five mice each; normal, negative, and positive control groups received 1 mL/kg of distilled water, paracetamol 250 mg/kg only, and silymarin (100 mg/kg) orally with paracetamol, respectively. While treatment groups I, II, and III received 200, 400, and 600 mg/kg of the Results: The negative control group showed higher levels of ALT, AST, ALP, GGT, and bilirubin compared to the normal control. However, significant hepatoprotective effects were noted in the treatment and positive control groups, as evidenced by the substantially reduced levels of these liver biomarkers towards the normal range. The significantly lower levels of indirect bilirubin were seen among treatment groups II and III as compared to group II. Abnormal liver architectures were observed in the negative control group; however, these changes were reversed following administration of the leaf extract. Conclusion: The study found that the methanolic leaf extract of
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