SynthesisFrontiers in aging neuroscience2025
Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cognitive dysfunction is a common impairment observed in individuals with Multiple Sclerosis (MS), affecting key domains such as attention, information processing speed, memory, and executive functions. This deficit is typically identified through comprehensive neuropsychological assessments, which represent the gold standard for cognitive evaluation. In recent years, increasing efforts have been made to integrate neuropsychological findings with advanced neuroimaging techniques to better understand the neural substrates of cognitive dysfunction. Among these, Diffusion Tensor Imaging (DTI) has emerged as a valuable tool for investigating microstructural changes in white matter (WM) that may underlie cognitive deficits in MS. However, despite its clinical utility, the pathophysiological mechanisms contributing to cognitive impairment, particularly in subjects with Relapsing-Remitting MS (RRMS), remain complex and not yet fully understood. This review focuses on studies investigating WM alterations measured by DTI and their correlation with cognitive dysfunction as assessed through neuropsychological testing. Method: Papers were identified by searching in PubMed, Embase, Web of Science and Scopus databases from 2002 - the years, of first related published article, - to December 2024. From the initial 853, we included only 34 studies that met to eligibility criteria. Results: In subjects with RRMS, WM alterations, assessed through DTI, were found to correlate with cognitive dysfunction, as measured by standardized neuropsychological tests. These alterations were observed both in global WM and in specific regions, including the corpus callosum, thalamus, hippocampus, cerebellar structure, cingulum, and cerebral fascicles. Conclusion: These findings underscore the relevance of integrating neuropsychological assessment with advanced neuroimaging techniques, such as DTI, to enhance our understanding of cognitive impairment in RRMS. DTI-derived measures of WM integrity show promise as potential biomarkers of cognitive dysfunction, while cognitive profiling can help localize underlying neuropsychological damage. This integrated approach may improve early detection of cognitive alterations and support the development of targeted therapeutic strategies aimed at preserving cognitive functioning in individuals with MS. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251073195, Identifier CRD420251073195.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.