ArticleFrontiers in public health2025
Association between sepsis and all-cause and cause-specific premature mortality: a prospective cohort study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Objective: This study aimed to examine the association between sepsis, including its subtypes, and all-cause and cause-specific premature mortality. Methods: This population-based prospective cohort study included 371,558 participants from the UK Biobank recruited between 2006 and 2010. Sepsis was identified from hospital records using ICD-10 codes. Cox proportional-hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for premature mortality. Results: Among 371,558 participants, 47,149 (12.7%) were diagnosed with sepsis, including 21,148 with implicit sepsis, 620 with explicit sepsis, and 25,381 with both. Sepsis was associated with a higher risk of all-cause premature mortality (aHR 2.36, 95% CI 2.26-2.46). Cause-specific analyses showed elevated risks for cardiovascular (aHR 2.35, 95% CI 2.18-2.54), respiratory (aHR 7.30, 95% CI 6.23-8.55), cancer-related (aHR 1.76, 95% CI 1.66-1.87), and infection-related premature mortality (aHR 9.75, 95% CI 6.97-13.62). Participants with explicit sepsis alone had elevated risk of all-cause mortality (aHR 1.72, 95% CI 1.21-2.45), which was lower than implicit sepsis alone (aHR 2.05, 95% CI 1.94-2.17) and highest for those with both implicit and explicit sepsis (aHR 2.60, 95% CI 2.48-2.73). Risks were more pronounced in participants with older age, multiple comorbidities, and unhealthy lifestyle ( Conclusion: Sepsis, especially implicit and combined implicit-explicit sepsis, was associated with increased risks of all-cause and cause-specific premature mortality. These associations were stronger in older participants, those with comorbidities, and unhealthy lifestyles.
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