Article in Analytical cellular pathology (Amsterdam), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Runhan ZhaoDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0002-5681-7568
Yanran HuangDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0001-8064-4006
Xiao QuDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0009-0009-4639-3392
Jun ZhangDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0002-6798-6156
Dagang TangDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0009-0008-0380-3470
Zhou XieDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0009-0001-1743-0010
Xiaoji LuoDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0002-3783-9438
Zefang LiDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0000-0003-0750-4642
Ningdao LiDepartment of Orthopaedic Surgery, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0009-0000-6627-8476
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Background: Ankylosing spondylitis (AS) is an autoimmune disease characterized by low back stiffness and pain, with no cure and a dearth of therapeutic targets. Methods: Identifying novel AS targets from a list of 5884 druggable genes using weighted gene coexpression network analysis (WGCNA), machine learning, and Mendelian randomization analysis. Investigating the biological functions of the targets through comprehensive bio-functional analyses; exploring immune-related functions of the targets based on single-cell analyses; developing a reliable AS risk prediction model based on the identified targets and clinical data; conducting target drug prediction and molecular docking based on the Enrichr database and the LeDock software. Results: A novel AS target, diazepam binding inhibitor (DBI), was identified from among 5884 druggable genes. Bio-functional enrichment analysis indicated that this gene plays a key role in AS by modulating lipid metabolism disorders. Furthermore, single-cell analysis revealed that the gene likely influences the onset or progression of AS by impairing the cytotoxic function of CD56 Conclusion: In this study, a novel therapeutic target for AS was identified using multiple algorithms, and it was found to be involved in lipid metabolism and cytotoxic function of CD56
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
DBI Mediates the Progression of Ankylosing Spondylitis by Regulating CD56 · full record | OpenQuestion