ArticleJournal of translational autoimmunity2025
Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data.
Article in Journal of translational autoimmunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Observational studies have suggested a potential association between autoimmune diseases and anemia, but the direction of causality remains unclear. To investigate the potential causal relationship between autoimmune diseases and anemia using Mendelian randomization (MR). Methods: We conducted a bidirectional two-sample MR study using summary-level genetic data from the EBI and FinnGen databases. We examined 21 autoimmune diseases as exposures and anemia as the outcome, and vice versa. Multivariable MR, meta-analysis, and two-step mediation analysis involving 43 candidate mediators were also performed. Proteomic MR and colocalization analyses were used to validate causal relationships involving proteins. Functional annotations including KEGG pathway, GO enrichment, protein-protein interaction networks, and drug enrichment analyses were performed to identify potential therapeutic targets. Results: Genetically determined type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), and primary biliary cholangitis (PBC) were associated with an increased risk of anemia ( Conclusion: This MR study supports a causal effect of certain autoimmune diseases on anemia risk and highlights potential protein targets for intervention, offering new insights for anemia prevention and treatment.
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