ReviewFrontiers in bioengineering and biotechnology2025
Microenvironment-responsive peptide hydrogels: molecular mechanisms, design and frontiers.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Hydrogels-Advanced Polymer Platforms for Drug Delivery.Polymers · 2026Review
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- pH/ROS-responsive smart hydrogels for infection control and immune microenvironment modulation in chronic wound healing.Frontiers in cell and developmental biology · 2026Review
- Advances in Injectable miRNA-Loaded Nanocomposite Hydrogel Systems for Cartilage Repair in KOA.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Responsive peptide hydrogels are advanced platforms for wound management because they can dynamically interact with the wound microenvironment. These smart materials respond to specific biochemical cues such as pH, reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and glucose (Glu), enabling precise control over drug release, enhancement of cellular repair, and suppression of infection. By adapting to pathological conditions like elevated pH, persistent oxidative stress, and enzymatic imbalances, peptide hydrogels promote efficient healing in chronic wounds. Recent advances have expanded their responsiveness to include physical stimuli like temperature, light, and magnetic fields, broadening their applicability in deep and complex wound treatments. Despite promising outcomes, challenges remain in optimizing biocompatibility, biodegradability, and stimulus precision. Future efforts will focus on developing multifunctional and personalized hydrogel systems to achieve smarter, minimally invasive therapeutic strategies for wound care and beyond.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.