ArticleNeuroscience applied2025
Functional connectivity differences in patients with mood disorders: an exploratory fMRI study comparing electroconvulsive therapy with pharmacological treatment.
Article in Neuroscience applied, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Electroconvulsive therapy (ECT) has been shown to induce widespread dysregulation of network connectivity in patients with mood disorders. Nevertheless, the extent to which these functional changes contribute to patients' cognitive side-effects or depressive symptoms improvement remains unclear. This study investigated cross-sectional resting-state functional connectivity (rs-FC) differences in patients with mood disorders after their 8th ECT session (ECT group, n = 33) compared to those receiving pharmacological treatment (non-ECT group, n = 36) and healthy controls (n = 34). Furthermore, we explored the association of rs-FC differences with cognitive side-effects and depressive symptom improvements assessed longitudinally in the ECT group. We focused on analyzing rs-FC within- and between the default mode network (DMN), executive control network (ECN), and frontoparietal network (FPN). Additionally, we explored the association between significant rs-FC group differences and verbal memory decline, and depressive symptoms improvement from pre-to post-ECT within the ECT group. ECT-treated patients exhibited
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