ArticleRegenerative therapy2025
Fabrication and characterization of a multilayered PVA/alginate-diopside electrospun scaffold for tissue engineering applications.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: One of the most effective methods for reproducing soft tissue is to apply multilayer soft tissue using the electrospinning technique, creating suitable conditions for wound healing. Methods: In this study, a new bio-nanocomposite composition consisting of polyvinyl alcohol (PVA), alginate (ALG), and diopside nanoparticles with different weight percentages was used, employing the electrospun technique to create a homogeniz Results: In general, due to the prolonged degradation of PVA and ALG, the study after three weeks reveals that significant weight changes have occurred in the samples containing the maximum amount of diopside nanoparticles. The FTIR analysis shows that the peaks corresponding to the C[bond, double bond]O, CH, and OH bonds remained unchanged. As a result, the absence of chemical interaction between PVA is proven. Tensile strength test showed that an increase in diopside nanoparticles disrupts the network chain and may lead to a decrease in the elastic modulus of the samples. The contact angle of the fiber arrangement was reduced from 151° to 121°, encompassing the lowest and highest amounts of diopside nanoparticles, respectively. According to the observations, the PVA nanocomposite scaffolds with 4 wt% diopside nanoparticles are suitable for soft texture engineering. Conclusions: Nanocomposite scaffolds containing 4 wt% diopside nanoparticles have suitable conditions for cellular testing due to their mechanical, physical, and morphological properties.
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