Evidence map›Paper›PMID 41323364›Full record

ReviewThe Lancet regional health. Europe2026

Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net).

Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, Yen Holicka, Troels Lillebaek, Rita Macedo, Mikael Mansjö, Viktoria Szél and 3 more

Abstract readReview
In one paragraph

Review in The Lancet regional health. Europe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesca SaluzzoDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Andrea Maurizio CabibbeDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Richard AnthonyNational Tuberculosis Reference Laboratory, IDS, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Alexandra AubryAP-HP. Sorbonne-Université, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Sorbonne Université, CNRS, Inserm, Centre d'Immunologie et des Maladies Infectieuses, CIMI, Paris, France.
Francis DrobniewskiDepartment of Infectious Disease, Imperial College London, London, UK.
Yen HolickaDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Troels LillebaekInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.
Rita MacedoNational Tuberculosis Reference Laboratory, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisboa, Portugal.
Mikael MansjöNational and WHO Supranational Reference Laboratory for Tuberculosis, Public Health Agency of Sweden, 171 82, Solna, Sweden.
Viktoria SzélNational Reference Laboratory for Mycobacteriology, National Koranyi Institute for Pulmonology, 1121, Budapest, Hungary.
Ljiljana ŽmakNational Reference Laboratory for Tuberculosis, Croatian Institute of Public Health, Zagreb, Croatia.
Daniela M CirilloDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Ramona GroenheitNational and WHO Supranational Reference Laboratory for Tuberculosis, Public Health Agency of Sweden, 171 82, Solna, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reported poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptation to the European Union/European Economic Area (EU/EEA) context, a setting with low TB incidence but high resources. This viewpoint from the European Reference Laboratory Network for TB (ERLTB-Net) proposes a tailored diagnostic algorithm that prioritises the universal use of WHO-recommended molecular rapid diagnostic tests, systematic culture, and whole genome sequencing (WGS). This approach integrates phenotypic drug susceptibility testing strategically and outlines the possible role of targeted next-generation sequencing (tNGS) in the EU/EEA setting. The algorithm also addresses the importance of diagnostic harmonisation, cross-border collaboration, and sustained investment in sequencing capacity. By aligning diagnostic practices with the regional epidemiology and laboratory infrastructure, this stepwise, resource-sensitive approach aims to strengthen TB control, improve treatment outcomes, and guide public health action in the EU/EEA.

Indexed as

Diagnostic algorithmsDrug resistanceEU/EEATuberculosisWhole genome sequencing

Identifiers

PMID41323364
PMCPMC12664343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.