Evidence map›Paper›PMID 41323275›Full record

ArticleiScience2025

The inherent fragility of collective proliferative control.

Michael G Caldwell, Arthur D Lander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael G CaldwellCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697-2300, USA.
Arthur D LanderCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697-2300, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Shared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAN ETTEN, RICHARD A. · 2018 to 2022
$9.7M
Understanding critical transitions in chronic myeloid leukemia to improve tyrosine kinase inhibitor therapyP01CA288662 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI John Lowengrub · 2025 to 2026
$6.4M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Mathematical, Computational and Systems BiologyT32EB009418 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, NIE, QING · 2009 to 2019
$2.4M
NCI NIH HHS P01 CA288662NCI NIH HHS P30 CA062203NCI NIH HHS U54 CA217378NIBIB NIH HHS T32 EB009418NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

Tissues achieve and maintain their sizes through active feedback, whereby cells collectively regulate proliferation and differentiation to facilitate homeostasis and the ability to respond to disturbances. One of the best understood feedback mechanisms-

Indexed as

Cancer biologyCell biologySystems biology

Identifiers

PMID41323275
PMCPMC12663686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.