Evidence map›Paper›PMID 41323271›Full record

ArticleiScience2025

Transcription factor Zfx regulates tumor's evasion to T cell killing in immunotherapy.

Ulrike Kaufmann, Joy Wang, Marinella G Callow, Jean-Philippe Fortin, Szymon Myrta, Dorothee Nickles, Rohit Reja, Eric Cheng, Erin Wonder, Benjamin Haley and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ulrike KaufmannDepartment of Translational Oncology, Genentech Inc., South San Francisco, CA, USA.
Joy WangDepartment of Translational Oncology, Genentech Inc., South San Francisco, CA, USA.
Marinella G CallowDepartment of Research Oncology, Genentech Inc., South San Francisco, CA, USA.
Jean-Philippe FortinDepartment of Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
Szymon MyrtaRoche Global IT Solution Center, Genentech Inc., South San Francisco, CA, USA.
Dorothee NicklesOncology Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
Rohit RejaOncology Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
Eric ChengDepartment of Translational Oncology, Genentech Inc., South San Francisco, CA, USA.
Erin WonderDepartment of Translational Oncology, Genentech Inc., South San Francisco, CA, USA.
Benjamin HaleyMolecular Biology, Genentech Inc., South San Francisco, CA, USA.
Yuxin LiangNext Generation Sequencing and Proteomics, Genentech Inc., South San Francisco, CA, USA.
Scott MartinDepartment of Research Oncology, Genentech Inc., South San Francisco, CA, USA.
Mike CostaDepartment of Research Oncology, Genentech Inc., South San Francisco, CA, USA.
Haochu HuangDepartment of Translational Oncology, Genentech Inc., South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy aims to boost T cell responses against tumor cells. However, a large fraction of patients with cancer exhibit intrinsic or acquired resistance to immunotherapy. To better understand resistance mechanisms in tumor cells, we used CRISPR-Cas9 whole-genome screening to uncover tumor-specific genes that influence sensitivity to T cell killing. Among the top hits, we identified the transcription factor zinc-finger protein X-linked (Zfx). Zfx knockout tumor cells are resistant to T cell killing both

Indexed as

oncology

Identifiers

PMID41323271
PMCPMC12661158

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.